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Products:Neuroscience >> Cell Adhesion Proteins >> Cytoskeletal Proteins >> Microtubules
Overview
Product name
Anti-MAP1B antibody [AA6]
See all MAP1B products (6) ...
Description
Mouse monoclonal [AA6] to MAP1B
Specificity
Monoclonal Anti-MAP1b does not react with tubulin of other Microtubule associated proteins.
Tested applications
WB, ICC/IFmore details
Cross reactivity
Reacts with
Mouse, Rat, Chicken, Hamster, Cow, Cat, Human
Immunogen
Rat brain microtubule associated proteins.
Positive control
Rat brain.
General notes
Storage in frost-free freezers is not recommended.
If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 15mM Sodium Azide
Concentration
Concentration information loading...
Purity
Ascites
Clonality
Monoclonal
Clone number
AA6
Isotype
IgG1
Research areas
Neuroscience >> Cell Type Marker >> Neuron marker >> Axon marker
Neuroscience >> Neurology process >> Neurogenesis
Tags & Cell Markers >> Cell Type Markers >> Neuroscience Markers >> Neuronal
Signal Transduction >> Cytoskeleton / ECM >> Cytoskeleton >> Microtubules >> MT Associated Proteins >> MAP
Neuroscience >> Cell Adhesion Proteins >> Cytoskeletal Proteins >> Microtubules
Applications
Show applications key
Our Abpromise guarantee covers the use of ab11266 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
ICC/IF
Application notes
ICC/IF: Use at an assay dependent dilution in conjunction with either immunofluorescence or immunoperoxidase labelling methods.
WB: 1/500. Predicted molecular weight: 270 kDa. May run higher due to many phosphorylation sites: 320kDa.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
Microtubules are associated with a family of proteins called microtubule associated proteins (MAPs), which includes the protein t (tau) and a group of proteins referred to as MAP1, MAP2, MAP3, MAP4 and MAP5. MAP1B is the major microtubule associated protein in developing brain which changes its expression during development. In the newborn rat brain, it is a major component of microtubules but in the adult its level is ten fold lower. This change in the level of expression occurs simultaneously with neuronal maturation. MAP1B is the first MAP to appear in growing axons during development as it is present from the first emergence of the nascent axon from the cell body.
Alternative names
- DKFZp686E1099 antibody
- DKFZp686F1345 antibody
- FLJ38954 antibody
see all
Database links
- Entrez Gene: 281910 Cow
- Entrez Gene: 4131 Human
- Entrez Gene: 17755 Mouse
- Entrez Gene: 29456 Rat
- Omim: 157129 Human
- SwissProt: P46821 Human
- SwissProt: P14873 Mouse
- SwissProt: P15205 Rat
see all
References for Anti-MAP1B antibody [AA6] (ab11266)
This product has been referenced in:
- Eriksson Met al. MAP1B binds to the NMDA receptor subunit NR3A and affects NR3A protein concentrations. Neurosci Lett 475:33-7 (2010). WB, ICC/IF; Rat.Read more (PubMed: 20304030) »
- Impens Fet al. Mechanistic insight into taxol-induced cell death. Oncogene 27:4580-91 (2008). WB; Human.Read more (PubMed: 18408750) »
See all 6 publications for this product
Publishing research using ab11266? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"