MAP1B antibody [AA6] (ab11266)

Product Name 

MAP1B antibody [AA6]

Product type 

Primary antibodies

Description 

Mouse monoclonal [AA6] to MAP1B

Immunogen 

Rat brain microtubule associated proteins.

Reacts with 
(species key)

Hu, Ms, Rat, Cat, Chk, Cow, Hm

Specificity 

Monoclonal Anti-MAP1b does not react with tubulin of other Microtubule associated proteins.

Tested applications 
(see key)

ICC/IF, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
ICC/IF: Use at an assay dependent dilution in conjunction with either immunofluorescence or immunoperoxidase labelling methods.
WB: 1/500. Predicted molecular weight: 270 kDa.

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

Rat brain.

Research areas 

Neuroscience >> Cell Type Marker >> Neuron marker >> Axon marker
Neuroscience >> Neurology process >> Neurogenesis
Tags & Cell Markers >> Cell Type Markers >> Neuroscience Markers >> Neuronal
Signal Transduction >> Cytoskeleton / ECM >> Cytoskeleton >> Microtubules >> MT Associated Proteins >> MAP
Neuroscience >> Cell Adhesion Proteins >> Cytoskeletal Proteins >> Microtubules

Relevance 

Microtubules are associated with a family of proteins called microtubule associated proteins (MAPs), which includes the protein t (tau) and a group of proteins referred to as MAP1, MAP2, MAP3, MAP4 and MAP5.
MAP1B is the major microtubule associated protein in developing brain which changes its expression during development. In the newborn rat brain, it is a major component of microtubules but in the adult its level is ten fold lower. This change in the level of expression occurs simultaneously with neuronal maturation. MAP1B is the first MAP to appear in growing axons during development as it is present from the first emergence of the nascent axon from the cell body.

Database links 

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

AA6

Isotype 

IgG1

Purity 

Ascites

Storage buffer 

Preservative: 15mM Sodium Azide

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

4.100 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Notes 

Storage in frost-free freezers is not recommended.
If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

References for MAP1B antibody [AA6] (ab11266)

  This product has been used in: (two most recent references)

Impens F et al. Mechanistic insight into taxol-induced cell death. Oncogene 27:4580-91 (2008). WB; Human. PubMed: 18408750

Davidkova G & Carroll RC Characterization of the role of microtubule-associated protein 1B in metabotropic glutamate receptor-mediated endocytosis of AMPA receptors in hippocampus. J Neurosci 27:13273-8 (2007). PubMed: 18045921

See all 5 publication references for this product.


If you publish research using ab11266 please let us know so that we can cite the reference on this datasheet.

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