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Products:Cardiovascular >> Blood >> Other

Anti-MAPKAP Kinase 2 antibody [E341] (ab32567)

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Overview

Product name

Anti-MAPKAP Kinase 2 antibody [E341]
See all MAPKAP Kinase 2 products (8) ...

Description

Rabbit monoclonal [E341] to MAPKAP Kinase 2

Specificity

ab32567 recognises MAPKAP Kinase-2.

Tested applications

WB, IPmore details

Cross reactivity

Reacts with

Mouse, Rat, Human

Immunogen

A synthetic peptide corresponding to residues near C-terminus of human MAPKKAP Kinase-2.

Positive control

Hela cell lysate.

General notes

Produced under U.S. Patent No. 5,675,063.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%

Concentration

Concentration information loading...

Purity

IgG fraction

Clonality

Monoclonal

Clone number

E341

Isotype

IgG

Research areas

Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> MAPK Pathway
Signal Transduction >> Cytoskeleton / ECM >> Cytoskeleton >> Microfilaments >> Actin etc >> Actin
Cardiovascular >> Blood >> Other

  • Western blot - MAPKAP Kinase 2 antibody [E341] (ab32567)Western blot - MAPKAP Kinase 2 antibody [E341] (ab32567) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab32567 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

IP: 1/200.
WB: 1/500 - 1/1000. Detects a band of approximately 46 kDa (predicted molecular weight: 46 kDa).

Is unsuitable for FACS, ICC or IHC.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25). In vitro can phosphorylate glycogen synthase at 'Ser-7' and tyrosine hydroxylase (on 'Ser-19' and 'Ser-40'). This kinase phosphorylates Ser in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue (By similarity). Mediates both ERK and p38 MAPK/MAPK14 dependent neutrophil responses. Participates in TNF alpha-stimulated exocytosis of secretory vesicles in neutrophils. Plays a role in phagocytosis-induced respiratory burst activity.

Tissue specificity

Expressed in all tissues examined.

Sequence similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Contains 1 protein kinase domain.

Post-translational
modifications

Phosphorylated and activated by MAP kinase.

Target information above from: UniProt accessionP49137 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • MAP Kinase Activated Protein Kinase 2 antibody
  • MAP kinase-activated protein kinase 2 antibody
  • MAPK activated protein kinase 2 antibody
  • MAPK-activated protein kinase 2 antibody
  • MAPK2_HUMAN antibody
  • MAPKAP K2 antibody
  • MAPKAP kinase 2 antibody
  • MAPKAPK 2 antibody
  • MAPKAPK-2 antibody
  • MAPKAPK2 antibody
  • Mitogen Activated Protein Kinase Activated Protein Kinase 2 antibody
  • MK 2 antibody
  • MK2 antibody
see all

Database links

see all

Anti-MAPKAP Kinase 2 antibody [E341] images:

  Western blot - MAPKAP Kinase 2 antibody [E341] (ab32567)

Western blot - MAPKAP Kinase 2 antibody [E341] (ab32567)

Anti-MAPKAP Kinase 2 antibody [E341] (ab32567) at 1/1000 dilution + Hela cell lysate

Predicted band size : 46 kDa
Observed band size : 46 kDa

References for Anti-MAPKAP Kinase 2 antibody [E341] (ab32567)

ab32567 has not yet been referenced specifically in any publications.

Publishing research using ab32567? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"