Anti-MAPKAP Kinase 2 antibody (ab2311)

Overview

  • Product nameAnti-MAPKAP Kinase 2 antibody
    See all MAPKAP Kinase 2 primary antibodies
  • Description
    Rabbit polyclonal to MAPKAP Kinase 2
  • SpecificityTwo isoforms are produced due to alternative splicing of the same gene which differ in their C-terminals. This antibody recognizes both 43 and 60 kDa isoforms, corresponding to the apparent molecular mass of MAPKAPK-2 on SDS-PAGE immunoblots. These 43 kDa and 60 kDa bands can be specifically inhibited by the relevant peptide.
  • Tested applicationsIP, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Cow, Dog, Human
  • Immunogen

    Unfortunately, this information is considered to be commercially sensitive

Properties

Applications

Our Abpromise guarantee covers the use of ab2311 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use a concentration of 4 µg/ml.
WB Use a concentration of 4 µg/ml.

Target

  • FunctionIts physiological substrate seems to be the small heat shock protein (HSP27/HSP25). In vitro can phosphorylate glycogen synthase at 'Ser-7' and tyrosine hydroxylase (on 'Ser-19' and 'Ser-40'). This kinase phosphorylates Ser in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue (By similarity). Mediates both ERK and p38 MAPK/MAPK14 dependent neutrophil responses. Participates in TNF alpha-stimulated exocytosis of secretory vesicles in neutrophils. Plays a role in phagocytosis-induced respiratory burst activity.
  • Tissue specificityExpressed in all tissues examined.
  • Sequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Phosphorylated and activated by MAP kinase.
  • Information by UniProt
  • Database links
  • Alternative names
    • MAP Kinase Activated Protein Kinase 2 antibody
    • MAP kinase-activated protein kinase 2 antibody
    • MAPK activated protein kinase 2 antibody
    • MAPK-activated protein kinase 2 antibody
    • MAPK2_HUMAN antibody
    • MAPKAP K2 antibody
    • MAPKAP kinase 2 antibody
    • MAPKAPK 2 antibody
    • MAPKAPK-2 antibody
    • MAPKAPK2 antibody
    • Mitogen Activated Protein Kinase Activated Protein Kinase 2 antibody
    • MK 2 antibody
    • MK2 antibody
    see all

References for Anti-MAPKAP Kinase 2 antibody (ab2311)

ab2311 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. The immunogen used to raise this Ab is a synthetic peptide mapping to the C-terminus of human MAPKAP2. The full immunogenic sequence is deemed to be commercially sensitive by the originator. We only supply one other Ab t...

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Thank you so much for your patience. For both blots your customer has done, they are definitely having a problem with non-specific bands. They have decreased the concentration of the primary, but have they checked that these bands are not coming from t...

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The immunogen is peptide arround a.a. 350 of human MAPKAPK-2. It does not include portion of aa 1-320.

All the tested applications for each of our products are specified on the datasheets. This antibody has not yet been tested in IHC. However, if you decide to go ahead and purchase it please let us know how you get on and in return we will forward a rew...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"