Anti-MAPKAP Kinase 2 (phospho S272) antibody (ab59998)

Overview

• Product nameAnti-MAPKAP Kinase 2 (phospho S272) antibodySee all MAPKAP Kinase 2 primary antibodies ...
• Description
  Rabbit polyclonal to MAPKAP Kinase 2 (phospho S272)
• Tested applicationsELISA, IHC-P more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic phosphopeptide corresponding to amino acid residues surrounding S272 of human MAPKAP Kinase 2 conjugated to KLH

• Positive controlHuman hepatocarcinoma tissue.

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityProtein G purified
• Purification notesab59998 is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Kinases
  • MAPK Pathway

  • Signal Transduction
  • Cytoskeleton / ECM
  • Cytoskeleton
  • Microfilaments
  • Actin etc
  • Actin

  • Cardiovascular
  • Blood
  • Other

Applications

Target

• FunctionIts physiological substrate seems to be the small heat shock protein (HSP27/HSP25). In vitro can phosphorylate glycogen synthase at 'Ser-7' and tyrosine hydroxylase (on 'Ser-19' and 'Ser-40'). This kinase phosphorylates Ser in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue (By similarity). Mediates both ERK and p38 MAPK/MAPK14 dependent neutrophil responses. Participates in TNF alpha-stimulated exocytosis of secretory vesicles in neutrophils. Plays a role in phagocytosis-induced respiratory burst activity.
• Tissue specificityExpressed in all tissues examined.
• Sequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
  Contains 1 protein kinase domain.
• Post-translational
  modificationsPhosphorylated and activated by MAP kinase.

Target information above from: UniProt accession P49137 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 9261 Human
  • Omim: 602006 Human
  • SwissProt: P49137 Human
  • Unigene: 643566 Human
  • Unigene: 713747 Human

• Alternative names
  MAP kinase activated protein Kinase 2 antibodyMAP kinase-activated protein kinase 2 antibodyMAPK activated protein kinase 2 antibody

  MAPK-activated protein kinase 2 antibodyMAPK2_HUMAN antibodyMAPKAP K2 antibodyMAPKAP kinase 2 antibodyMAPKAPK 2 antibodyMAPKAPK-2 antibodyMAPKAPK2 antibodyMitogen activated protein kinase activated protein kinase 2 antibodyMK 2 antibodyMK2 antibody

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Anti-MAPKAP Kinase 2 (phospho S272) antibody images

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MAPKAP Kinase 2 (phospho S272) antibody (ab59998)
  ab59998 at 1/50 dilution staining MAPKAP Kinase 2 in Human hepatocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. The primary antibody was peroxidase-conjugated to the secondary antibody, followed by AEC staining