Anti-MAPKAP Kinase 2 (phospho S272) antibody (ab59998)

Overview

  • Product nameAnti-MAPKAP Kinase 2 (phospho S272) antibodySee all MAPKAP Kinase 2 primary antibodies ...
  • Description
    Rabbit polyclonal to MAPKAP Kinase 2 (phospho S272)
  • Tested applicationsELISA, IHC-P more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic phosphopeptide corresponding to amino acid residues surrounding S272 of human MAPKAP Kinase 2 conjugated to KLH

  • Positive control
    • Human hepatocarcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab59998 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ELISA 1/1000.
IHC-P 1/50 - 1/100.

Target

  • FunctionIts physiological substrate seems to be the small heat shock protein (HSP27/HSP25). In vitro can phosphorylate glycogen synthase at 'Ser-7' and tyrosine hydroxylase (on 'Ser-19' and 'Ser-40'). This kinase phosphorylates Ser in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue (By similarity). Mediates both ERK and p38 MAPK/MAPK14 dependent neutrophil responses. Participates in TNF alpha-stimulated exocytosis of secretory vesicles in neutrophils. Plays a role in phagocytosis-induced respiratory burst activity.
  • Tissue specificityExpressed in all tissues examined.
  • Sequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Phosphorylated and activated by MAP kinase.
  • Target information above from: UniProt accession P49137 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Alternative names
    • MAP kinase activated protein Kinase 2 antibody
    • MAP kinase-activated protein kinase 2 antibody
    • MAPK activated protein kinase 2 antibody
    • MAPK-activated protein kinase 2 antibody
    • MAPK2_HUMAN antibody
    • MAPKAP K2 antibody
    • MAPKAP kinase 2 antibody
    • MAPKAPK 2 antibody
    • MAPKAPK-2 antibody
    • MAPKAPK2 antibody
    • Mitogen activated protein kinase activated protein kinase 2 antibody
    • MK 2 antibody
    • MK2 antibody
    see all

Anti-MAPKAP Kinase 2 (phospho S272) antibody images

  • ab59998 at 1/50 dilution staining MAPKAP Kinase 2 in Human hepatocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. The primary antibody was peroxidase-conjugated to the secondary antibody, followed by AEC staining

References for Anti-MAPKAP Kinase 2 (phospho S272) antibody (ab59998)

ab59998 has not yet been referenced specifically in any publications.

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