Anti-MARK2 antibody (ab54997)

Overview

• Product nameAnti-MARK2 antibodySee all MARK2 primary antibodies ...
• Description
  Mouse monoclonal to MARK2
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Recombinant Fragment
  Predicted to work with: Human
• Immunogen

  Recombinant fragment: QAAGPAIPTS NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST NRSRNSPLLE RASLGQASIQ NGKDSLTMPG , corresponding to amino acids 401-500 of Human MARK2

  Run BLAST with Run BLAST with

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  PBS, pH 7.2
• Concentration information loading...
• PurityProtein G purified
• Clonality Monoclonal
• IsotypeIgG2a
• Light chain typekappa
• Research Areas
  • Signal Transduction
  • Cytoskeleton / ECM
  • Cytoskeleton
  • Microtubules
  • MT Associated Proteins
  • MARK

  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Kinases
  • Other Kinases

Applications

Target

• FunctionRole in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may play a role in graft rejection.
• Tissue specificityHigh levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney.
• Sequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily.
  Contains 1 KA1 (kinase-associated) domain.
  Contains 1 protein kinase domain.
  Contains 1 UBA domain.
• Cellular localizationCell membrane. Phosphorylated by PRKCZ in polarized epithelial cells, resulting in an interaction with YWHAZ which promotes relocation from the lateral to the apical membrane.

Target information above from: UniProt accession Q7KZI7 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 2011 Human
  • Entrez Gene: 2011 Human
  • Entrez Gene: 2011 Human
  • Omim: 600526 Human
  • SwissProt: Q7KZI7 Human
  • SwissProt: Q7KZI7 Human
  • SwissProt: Q7KZI7 Human
  • Unigene: 567261 Human

• Alternative names
  EC 2.7.11.1 antibodyELKL motif kinase 1 antibodyELKL motif kinase antibody

  EMK-1 antibodyEMK1 antibodyMAP/microtubule affinity regulating kinase 2 antibodyMAP/microtubule affinity-regulating kinase 2 antibodyMark2 antibodyMARK2_HUMAN antibodyMGC99619 antibodyPAR 1 antibodyPar 1b antibodyPAR1 homolog antibodyPar1b antibodySer/Thr protein kinase PAR 1B antibodySerine/threonine protein kinase EMK antibodySerine/threonine protein kinase MARK2 antibodySerine/threonine-protein kinase MARK2 antibody

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Anti-MARK2 antibody images

• 

  Western blot - MARK2 antibody (ab54997)
  Western blot against tagged recombinant protein immunogen using ab54997 MARK2 antibody at 1ug/ml. Predicted band size of immunogen is 34 kDa.

  This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.