Overview

  • Product nameAnti-MARK2 antibodySee all MARK2 primary antibodies ...
  • Description
    Goat polyclonal to MARK2
  • SpecificityExpected to recognize both reported isoforms b and c (NP_004945.3 and NP_001034557.1).
  • Tested applicationsWB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Synthetic peptide:

    C-QNGKDSTAPQR

    , corresponding to internal sequence amino acids 499-509 of Human MARK2 (NP_001034557.1)

  • Positive control
    • Human Brain (Cerebellum) lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab77641 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesPeptide ELISA: Use at an assay dependent dilution. Antibody detection limit dilution: 1/16000.
    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 70 kDa (predicted molecular weight: 77 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionRole in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may play a role in graft rejection.
    • Tissue specificityHigh levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney.
    • Sequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily.
      Contains 1 KA1 (kinase-associated) domain.
      Contains 1 protein kinase domain.
      Contains 1 UBA domain.
    • Cellular localizationCell membrane. Phosphorylated by PRKCZ in polarized epithelial cells, resulting in an interaction with YWHAZ which promotes relocation from the lateral to the apical membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • EC 2.7.11.1 antibody
      • ELKL motif kinase 1 antibody
      • ELKL motif kinase antibody
      • EMK-1 antibody
      • EMK1 antibody
      • MAP/microtubule affinity regulating kinase 2 antibody
      • MAP/microtubule affinity-regulating kinase 2 antibody
      • Mark2 antibody
      • MARK2_HUMAN antibody
      • MGC99619 antibody
      • PAR 1 antibody
      • Par 1b antibody
      • PAR1 homolog antibody
      • Par1b antibody
      • Ser/Thr protein kinase PAR 1B antibody
      • Serine/threonine protein kinase EMK antibody
      • Serine/threonine protein kinase MARK2 antibody
      • Serine/threonine-protein kinase MARK2 antibody
      see all

    Anti-MARK2 antibody images

    References for Anti-MARK2 antibody (ab77641)

    ab77641 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"