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Products:Cardiovascular >> Angiogenesis >> Adhesion / ECM >> Integrins
Overview
Product name
Anti-MAdCAM1 antibody [CA102.2C1 ]
See all MAdCAM1 products (10) ...
Description
Mouse monoclonal [CA102.2C1 ] to MAdCAM1
Specificity
ab11203 recognises human MAdCAM1, a protein expressed by vascular endothelium. Clone CA102.2C1 has been reported to block the binding of human cells expressing alpha 4 Beta 7 to immobilized MAdCAM1 in vitro.
Tested applications
ELISA, WB, Functional Studiesmore details
Cross reactivity
Reacts with
Human
Immunogen
Bacterially expressed human MAdCAM1
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C (add glycerol to a final volume of 50% for extra stability). Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Monoclonal
Clone number
CA102.2C1
Isotype
IgG1
Research areas
Neuroscience >> Cell Adhesion Proteins >> Receptors >> Integrins >> Beta Integrins
Signal Transduction >> Cytoskeleton / ECM >> Cell Adhesion >> Integrins >> Beta
Immunology >> Innate Immunity >> Macrophage / Inflamm.
Cardiovascular >> Angiogenesis >> Adhesion / ECM >> Integrins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab11203 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 40 kDa.
FuncS: Use at an assay dependent dilution.
Target
Function
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
Tissue specificity
Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes.
Sequence similarities
Contains 2 Ig-like (immunoglobulin-like) domains.
Post-translational
modifications
The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation.
Cellular localization
Membrane.
Target information above from: UniProt accessionQ13477
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Addressin mucosal antibody
- hMAdCAM 1 antibody
- hMAdCAM-1 antibody
see all
Database links
- Entrez Gene: 8174 Human
- Omim: 102670 Human
- SwissProt: Q13477 Human
- SwissProt: Q5UGI7 Human
- Unigene: 102598 Human
References for Anti-MAdCAM1 antibody [CA102.2C1 ] (ab11203)
ab11203 has not yet been referenced specifically in any publications.
Publishing research using ab11203? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"