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Product Name
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MAdCAM1 antibody [MECA-367] (FITC)
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See all MAdCAM1 antibodies (10)...
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Product type
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Primary antibodies
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Description
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Rat monoclonal [MECA-367] to MAdCAM1 (FITC)
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Immunogen
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Tissue / cell preparation: Endothelial cells isolated from BALB/c mouse mesenteric and peripheral lymph nodes.
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Reacts with
(species key)
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Ms
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Epitope
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This antibody reacts with an epitope located in the first domain of MAdCAM1.
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Tested applications
(see key)
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AP, BL, Flow Cyt, IHC-Fr, IP, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
AP: Use at an assay dependent dilution.
BL: Use at an assay dependent dilution.
Note: This antibody is useful for in vitro cellular binding blocking, and for blocking lymphocyte homing to Peyers patch HEV in vivo.
Flow Cyt: Use at an assay dependent dilution.
IHC-Fr: Use at a concentration of 1 µg/ml.
IP: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 44 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Membrane; single pass type I membrane protein.
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Research areas
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Neuroscience >> Cell Adhesion Proteins >> Receptors >> Integrins >> Beta Integrins
Signal Transduction >> Cytoskeleton / ECM >> Cell Adhesion >> Integrins >> Beta
Immunology >> Innate Immunity >> Macrophage / Inflamm.
Cardiovascular >> Angiogenesis >> Adhesion / ECM >> Integrins
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Relevance
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The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM1 (alpha4 beta7), L selectin, and VLA4 (alpha4 beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full length nature of some variants has not been determined.
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Database links
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The links below go to external sites and will open in a new browser window Entrez Gene | | 17123 (Mouse)
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Raised in
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Rat
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Clonality
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Monoclonal
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Clone number
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MECA-367
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Isotype
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IgG2a
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Light chain type
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kappa
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Purity
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IgG fraction
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Storage buffer
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Preservative: 0.1% Sodium Azide
Constituents: PBS Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Conjugation
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Fluorescein
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Concentration
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0.500 mg/ml
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Storage instructions
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Store at +4°C in the dark.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this MAdCAM1 antibody [MECA-367] (FITC) is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to MAdCAM1
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MAdCAM1 antibody [MECA-367] (FITC) - more information
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