Overview

  • Product name
    MC 1293
  • Description
    Histone deacetylase inhibitor
  • Biological description
    Histone deacetylase inhibitor (IC50 values are 4.5 and 1.9 μM for HDAC1 and HD2 respectively). Induces latent HIV-1 reactivation by histone modification.

Properties

  • Chemical name
    (E)-N-Hydroxy-3-[1-methyl-4-(4-methylbenzoyl)pyrrol-2-yl]prop-2-enamide
  • Molecular weight
    284.31
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C16H16N2O3
  • PubChem identifier
    10401611
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC1=CC=C(C=C1)C(=O)C2=CN(C(=C2)/C=C/C(=O)NO)C
  • Source

    Synthetic

References

This product has been referenced in:
  • Qu X  et al. Histone deacetylase inhibitor MC1293 induces latent HIV-1 reactivation by histone modification in vitro latency cell lines. Curr HIV Res 11:24-9 (2013). Read more (PubMed: 23092175) »
  • Hämäläinen M  et al. Inhibition of iNOS expression and NO production by anti-inflammatory steroids. Reversal by histone deacetylase inhibitors. Pulm Pharmacol Ther 21:331-9 (2008). Read more (PubMed: 17913526) »

See 0 Publications for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab144505.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

Sign up