Anti-MCL1 antibody [38G3] - Aminoterminal end (ab49435)

Overview

• Product nameAnti-MCL1 antibody [38G3] - Aminoterminal endSee all MCL1 primary antibodies ...
• Description
  Mouse monoclonal [38G3] to MCL1 - Aminoterminal end
• Tested applicationsIHC-P more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Recombinant fragment corresponding to a 255 amino acid fragment of the N terminal region of human MCL1

• Positive controlHuman small intestine tissue

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 15mM Sodium Azide
  Constituents: Tissue culture supernatant
• PurityTissue culture supernatant
• Clonality Monoclonal
• Clone number38G3
• MyelomaP3-NS1/1-Ag4-1
• IsotypeIgG1
• Research Areas
  • Metabolism
  • Pathways and Processes
  • Metabolism processes
  • Apoptosis

  • Cancer
  • Invasion/microenvironment
  • Apoptosis
  • Bcl 2 family

  • Cell Biology
  • Apoptosis
  • Intracellular
  • Bcl2 Family

Applications

Target

• FunctionInvolved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
• Sequence similaritiesBelongs to the Bcl-2 family.
• Post-translational
  modificationsCleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.
  Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region.
  Phosphorylated on Thr-163. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.
• Cellular localizationMembrane. Cytoplasm. Mitochondrion. Nucleus > nucleoplasm. Cytoplasmic, associated with mitochondria.

Target information above from: UniProt accession Q07820 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 4170 Human
  • Omim: 159552 Human
  • SwissProt: Q07820 Human
  • Unigene: 632486 Human

• Alternative names
  Bcl 2 related protein EAT/mcl1 antibodyBcl-2-like protein 3 antibodyBcl-2-related protein EAT/mcl1 antibody

  BCL2 related antibodyBcl2-L-3 antibodyBCL2L3 antibodyEAT antibodyInduced myeloid leukemia cell differentiation protein Mcl 1 antibodyInduced myeloid leukemia cell differentiation protein Mcl-1 antibodyMCL 1 antibodyMCL1 antibodyMCL1-ES antibodyMcl1/EAT antibodyMCL1_HUMAN antibodyMCL1L antibodyMCL1S antibodyMGC104264 antibodyMGC1839 antibodyMyeloid Cell Leukemia 1 antibodyMyeloid cell leukemia ES antibodymyeloid cell leukemia sequence 1 antibodyMyeloid cell leukemia sequence 1 BCL2 related antibodyMyeloid cell leukemia sequence 1 isoform 1 antibodyOTTHUMP00000032794 antibodyOTTHUMP00000032795 antibodyTM antibody

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Anti-MCL1 antibody [38G3] - Aminoterminal end images

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  Immunohistochemistry (Paraffin-embedded sections) - MCL1 antibody [38G3] (ab49435)
  Immunohistochemical staining of paraffin embedded human small intestine tissue using ab49435 at 1:20 dilution. 60 minutes primary antibody incubation at 25^oC and standard ABC technique. Note cytoplasmic staining of differentiated epithelial cells of the villi