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Products:Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Synthesis >> Other
Overview
Product name
Anti-MCM6 antibody
See all MCM6 products (5) ...
Description
Goat polyclonal to MCM6
Tested applications
IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Synthetic peptide corresponding to a region between residue 775 and the C-terminus (residue 821) of Human MCM6 (NP_005906.2).
Positive control
Human colon adenocarcinoma. Mouse squamous cell carcinoma.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: 0.1% BSA, Tris buffered saline
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
affinity purified using an epitope specific to MCM6 immobilized on solid support.
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> Chromatin Binding Proteins >> DNA / RNA binding
Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Synthesis >> Other
Applications
Show applications key
Our Abpromise guarantee covers the use of ab84293 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: 1/100 - 1/500.
Target
Function
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Sequence similarities
Belongs to the MCM family.
Contains 1 MCM domain.
Post-translational
modifications
Phosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localization
Nucleus. Binds to chromatin during G1 and detach from it during S phase.
Target information above from: UniProt accessionQ14566
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- DNA replication licensing factor MCM6 antibody
- MCG40308 antibody
- Mcm6 antibody
see all
Database links
- Entrez Gene: 4175 Human
- Entrez Gene: 17219 Mouse
- Omim: 601806 Human
- SwissProt: Q14566 Human
- SwissProt: P97311 Mouse
- Unigene: 444118 Human
- Unigene: 4933 Mouse
Anti-MCM6 antibody images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MCM6 antibody (ab84293)
ab84293, at 1/250 dilution, staining MCM6 in formalin-fixed, paraffin-embedded human colon adenocarcinoma tissue by Immunohistochemistry using DAB detection.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MCM6 antibody (ab84293)
ab84293, at 1/250 dilution, staining MCM6 in formalin-fixed, paraffin-embedded mouse squamous cell carcinoma tissue by Immunohistochemistry using DAB detection.
References for Anti-MCM6 antibody (ab84293)
ab84293 has not yet been referenced specifically in any publications.
Publishing research using ab84293? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"