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Product Name
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MCP1 antibody [ECE.2]
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See all MCP1 antibodies (19)...
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Product type
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Primary antibodies
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Description
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Rat monoclonal [ECE.2] to MCP1
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Reacts with
(species key)
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Ms
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Specificity
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The antibody reacts with murine JE / MCP-1.
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Tested applications
(see key)
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ICC/IF, IHC-FoFr, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-Fo: Suggested working dilution of 1/150 (see PMID: 15829914).
ICC/IF: Suggested working dilution of 1/150 (see PMID: 15829914).
IHC-FoFr: Use at assay dependent dilution, (PMID 19920349).
WB: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Secreted
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Research areas
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Cancer >> Cancer Metabolism >> Response to hypoxia
Cardiovascular >> Atherosclerosis >> Vascular Inflammation >> Leukocyte recruitment >> Chemokines
Immunology >> Innate Immunity >> Chemokines >> Alpha Chemokines (CXC)
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Relevance
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This chemotactic factor attracts monocytes and basophils but not neutrophils or eosinophils and augments monocyte anti-tumor activity. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. It may be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
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Database links
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The links below go to external sites and will open in a new browser window Entrez Gene | | 20296 (Mouse)
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Raised in
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Rat
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Clonality
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Monoclonal
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Clone number
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ECE.2
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Isotype
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IgG1
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Purity
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IgG fraction
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Storage buffer
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PBS with 0.1% BSA 0.02% sodium azide pH7.2 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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0.100 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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Notes
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Monocyte chemotactic protein-1 (MCP-1) is also known as MCAF.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this MCP1 antibody [ECE.2] is on this datasheet. But please do contact us if you would like any reassurance! |
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References for MCP1 antibody [ECE.2] (ab8101)
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This product has been used in: (two most recent references)
Tieu BC et al. An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice. J Clin Invest 119:3637-51 (2009). IHC-FoFr; Mouse. PubMed: 19920349
Nishi T et al. Superoxide dismutase 1 overexpression reduces MCP-1 and MIP-1 alpha expression after transient focal cerebral ischemia. J Cereb Blood Flow Metab 25:1312-24 (2005). PubMed: 15829914
See all 3 publication references for this product.
If you publish research using ab8101 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to MCP1
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MCP1 antibody [ECE.2] - more information
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Contact Abcam with a Technical Enquiry about MCP1 antibody [ECE.2] |
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