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Products:Immunology >> Innate Immunity >> Chemokines >> Alpha Chemokines (CXC)
Overview
Product name
Anti-MCP1 antibody [ECE.2]
See all MCP1 products (22) ...
Description
Rat monoclonal [ECE.2] to MCP1
Specificity
The antibody reacts with murine JE / MCP-1.
Tested applications
ICC/IF, IHC-Fr, IHC-P, WBmore details
Cross reactivity
Reacts with
Mouse
Does not react with
Human
Immunogen
Synthetic peptide: LFKTASALRSSAPLNVKLTRKSEANASTT, corresponding to C terminal amino acids 102-130 of Mouse MCP1
LFKTASALRS SAPLNVKLTR KSEANASTT
General notes
Monocyte chemotactic protein-1 (MCP-1) is also known as MCAF.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 0.1% BSA, PBS
Concentration
Concentration information loading...
Purity
IgG fraction
Purification notes
0.2 µm filtered antibody solution
Clonality
Monoclonal
Clone number
ECE.2
Isotype
IgG1
Research areas
Cancer >> Cancer Metabolism >> Response to hypoxia
Cardiovascular >> Atherosclerosis >> Vascular Inflammation >> Leukocyte recruitment >> Chemokines
Immunology >> Innate Immunity >> Chemokines >> Alpha Chemokines (CXC)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab8101 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ICC/IF: 1/150(PubMed: 15829914)
IHC-Fr: Use at an assay dependent dilution. (PubMed: 19920349)
IHC-P
IHC-P: 1/50IHC-P: 1/50
WB
WB: 1/50WB: 1/50
Target
Function
Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
Sequence similarities
Belongs to the intercrine beta (chemokine CC) family.
Post-translational
modifications
Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.
Cellular localization
Secreted.
Target information above from: UniProt accessionP13500
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- HSMCR30 antibody
- C-C motif chemokine 2 antibody
- CCL 2 antibody
see all
Database links
- Entrez Gene: 20296 Mouse
- SwissProt: P10148 Mouse
- Unigene: 290320 Mouse
References for Anti-MCP1 antibody [ECE.2] (ab8101)
This product has been referenced in:
- Zhang Het al. Interferon-gamma induced adipose tissue inflammation is linked to endothelial dysfunction in type 2 diabetic mice. Basic Res Cardiol 106:1135-45 (2011).Read more (PubMed: 21826531) »
- Tieu BCet al. An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice. J Clin Invest 119:3637-51 (2009). IHC-Fr; Mouse.Read more (PubMed: 19920349) »
See all 4 publications for this product
Publishing research using ab8101? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"