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Overview

Product name

Anti-MCP1 antibody
See all MCP1 products (22) ...

Description

Rabbit polyclonal to MCP1

Specificity

The antibody reacts with human MCP-1 both natural and recombinant. The antigen specificity was assessed by ELISA. The antigen specificity was further assessed by immunoprecipitation and Western blot. No cross-reactivities with other cytokines have been detected.

Tested applications

Neutralising, WB, Inhibition Assay, IHC-Fr, ICCmore details

Cross reactivity

Reacts with

Human, Pig

General notes

Human monocyte chemotactic protein-1 (MCP-1) is also known as MCAF.

Properties

Form

Liquid

Storage instructions

Store at +4°C.

Storage buffer

Preservative: 0.02% Sodium Azide
Constituents: 0.1% BSA, PBS

Concentration

Concentration information loading...

Purity

IgG fraction

Purification notes

0.2 µm filtered

Clonality

Polyclonal

Isotype

IgG

Applications

Show applications key

Our Abpromise guarantee covers the use of ab7814 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide

    Neutralising

     Neut: Use at an assay de...Read more →

    Neut: Use at an assay dependent dilution. (For neutralization of biological activity in vitro dilutions have to be made according to the amount of MCP-1 to be inactivated. Before use in biological assays, the product must be filter sterilized and depending on the concentration to be used dialyzed against culture medium to remove the sodium azide added.)

  • ShowHide

    WB

     WB: 1/10Predicted molecu...Read more →

    WB: 1/10Predicted molecular weight: 11.9 kDa.

  • Inhibition Assay

     Inhib: 1/10

    Inhib: 1/10

  • IHC-Fr

     IHC-Fr: 1/10

    IHC-Fr: 1/10

  • ICC

     ICC: 1/10

    ICC: 1/10

Target

Function

Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Post-translational
modifications

Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.

Cellular localization

Secreted.

Target information above from: UniProt accessionP13500 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • HSMCR30 antibody
  • C-C motif chemokine 2 antibody
  • CCL 2 antibody
  • CCL2 antibody
  • CCL2_HUMAN antibody
  • Chemokine (C C motif) ligand 2 antibody
  • Chemokine C C motif ligand 2 antibody
  • Chemokine CC Motif Ligand 2 antibody
  • GDCF 2 antibody
  • GDCF 2 HC11 antibody
  • GDCF2 antibody
  • HC11 antibody
  • HSMCR30 antibody
  • JE antibody
  • MCAF antibody
  • MCP 1 antibody
  • MCP-1 antibody
  • MGC9434 antibody
  • Monocyte chemoattractant protein 1 antibody
  • Monocyte chemotactic and activating factor antibody
  • Monocyte chemotactic and activating factor antibody
  • Monocyte chemotactic protein 1 antibody
  • Monocyte secretory protein JE antibody
  • Monocyte secretory protein JE antibody
  • SCYA2 antibody
  • Small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig je) antibody
  • Small inducible cytokine A2 antibody
  • Small inducible cytokine subfamily A (Cys Cys), member 2 antibody
  • Small inducible cytokine subfamily A Cys Cys member 2 antibody
  • Small-inducible cytokine A2 antibody
  • SMC CF antibody
  • SMCCF antibody
see all

References for Anti-MCP1 antibody (ab7814)

This product has been referenced in:

  • Zakkar Met al. Dexamethasone arterializes venous endothelial cells by inducing mitogen-activated protein kinase phosphatase-1: a novel antiinflammatory treatment for vein grafts? Circulation 123:524-32 (2011). IF, IHC; Pig.Read more (PubMed: 21262999) »
  • Hubal MJet al. Inflammatory gene changes associated with the repeated-bout effect. Am J Physiol Regul Integr Comp Physiol 294:R1628-37 (2008). IHC-Fr; Human.Read more (PubMed: 18353886) »

See all 2 publications for this product

Publishing research using ab7814? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"