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Overview

  • Product nameMCSF protein (Active)See all MCSF proteins and peptides ...
  • Protein descriptionRecombinant fragment of Rat MCSF (amino acids 33-254) consisting of a disulfide-linked homodimer containing 2 x 222 amino acids chains, 50.4 kDa (calculated). (UniProt ID = Q8JZQ0).
  • Uniprot accessionQ8JZQ0
  • Protein length222 amino acids
  • Expression hostHEK 293 cells

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Biological activityThe ED50 of 3-4ng/ml is measured by its ability to stimulate the proliferation of Mouse M-NFS-60 cells.
  • FormLyophilised:It is recommended to reconstitute ab125758 in sterile PBS not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. Upon reconstitution MCSF should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
  • Storage instructionsStore at -20°C (desiccating conditions).This product is an active protein and may elicit a biological response in vivo, handle with caution.
  • Storage bufferConstituent: 99% PBS
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab125758 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Functional Studies FuncS: Use at an assay dependent dilution.
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        Colony stimulating factor 1Colony stimulating factor 1 (macrophage)Colony stimulating factor macrophage specific
        CSF 1CSF-1CSF1CSF1_HUMANCsfmLanimostimM CSFM-CSFMacrophage colony stimulating factorMacrophage Colony Stimulating Factor 1MCSFMGC31930Processed macrophage colony-stimulating factor 1
      see all
  • FunctionGranulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.
  • Post-translational
    modifications    Glycosylation and proteolytic cleavage yield different soluble forms. A high molecular weight soluble form is a proteoglycan containing chondroitin sulfate.
    Isoform 1 is N- and O-glycosylated. Isoform 3 is N-glycosylated.
  • Cellular localizationCell membrane and Secreted > extracellular space.

    • Target information above from: UniProt accession P09603 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for MCSF protein (Active) (ab125758)

    ab125758 has not yet been referenced specifically in any publications.

    Publishing research using ab125758 ? Please let us know so that we can cite the reference in this datasheet

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"