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Products:Signal Transduction >> Metabolism >> Plasma Membrane >> Channels
Overview
Product name
Anti-MCT2 antibody
See all MCT2 products (3) ...
Description
Goat polyclonal to MCT2
Specificity
This antibody recognises human monocarboxylate transporter 2 (MCT2). Northern blot analysis reveals expression of a larger transcript in most normal tissues compared to that which predominates in many cell lines and this may be reflected in the two bands identified by this antibody, in Western blots.
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide: SNAQSVTSERETNI, corresponding to amino acids 465-478, derived from C terminus of human MCT2.
SNAQSVTSER ETNI
Positive control
Raji cell lysates.
General notes
Storage in frost-free freezers is not recommended.
Should this product contain a precipitate we recommend microcentrifugation before use.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, Whole serum, Tris buffered saline, pH 7.3
Concentration
Concentration information loading...
Purity
Protein A purified
Purification notes
Purification prepared by affinity chromatography.
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of carbohydrates
Signal Transduction >> Metabolism >> Plasma Membrane >> Channels
Applications
Show applications key
Our Abpromise guarantee covers the use of ab11783 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
Application notes
WB: 1/200 - 1/500. Detects a band of approximately 40 kDa (predicted molecular weight: 58 kDa), and 60-70 kD in Raji cell lysates.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family 16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. MCT2 is a high affinity transporter that catalyzes the rapid transport of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate across the plasma membrane.
Cellular localization
Plasma membrane
Alternative names
- MCT antibody
- MonocarboxylateTransporter 2 antibody
- MOT2 antibody
see all
Database links
- Entrez Gene: 9194 Human
- Omim: 603654 Human
- SwissProt: O60669 Human
- Unigene: 439643 Human
References for Anti-MCT2 antibody (ab11783)
ab11783 has not yet been referenced specifically in any publications.
Publishing research using ab11783? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"