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Anti-ME1 antibody (ab55537)

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Overview

Product name

Anti-ME1 antibody
See all ME1 products (4) ...

Description

Mouse monoclonal to ME1

Tested applications

WBmore details

Cross reactivity

Reacts with

Human

Immunogen

Recombinant full length protein, corresponding to amino acids 1-573 of Human ME1

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
PBS, pH 7.2

Concentration

Concentration information loading...

Purity

Protein G purified

Clonality

Monoclonal

Isotype

IgG2b

Light chain type

kappa

Research areas

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Cell Biology >> Other Antibodies >> Oxidative Stress
Signal Transduction >> Metabolism >> Energy Metabolism

  • Western blot - ME1 antibody (ab55537)Western blot - ME1 antibody (ab55537) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab55537 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

WB: Use at a concentration of 1-5 µg/ml.

This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

ME1 is a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet.

Cellular localization

Cytoplasmic

Alternative names

  • Cytosolic malic enzyme 1 antibody
  • HUMNDME antibody
  • Malate dehydrogenase antibody
  • Malic enzyme 1 antibody
  • Malic enzyme 1, NADP(+) dependent, cytosolic antibody
  • Malic enzyme 1, soluble antibody
  • Malic enzyme, cytoplasmic antibody
  • MES antibody
  • NADP dependent malic enzyme antibody
  • NADP ME antibody
  • Pyruvic malic carboxylase antibody
see all

Database links

Anti-ME1 antibody images:

  Western blot - ME1 antibody (ab55537)

Western blot - ME1 antibody (ab55537)

Western blot against tagged recombinant protein immunogen using ab55537 ME1 antibody at 1ug/ml. Predicted band size of immunogen is 89 kDa

References for Anti-ME1 antibody (ab55537)

This product has been referenced in:

  • Pound KMet al. Substrate-enzyme competition attenuates upregulated anaplerotic flux through malic enzyme in hypertrophied rat heart and restores triacylglyceride content: attenuating upregulated anaplerosis in hypertrophy. Circ Res 104:805-12 (2009). WB.Read more (PubMed: 19213957) »

See 1 publication for this product

Publishing research using ab55537? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"