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Products:Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> Developmental Families >> HOX
Overview
Product name
Anti-MEIS1 antibody
See all MEIS1 products (3) ...
Description
Goat polyclonal to MEIS1
Tested applications
WB, ELISAmore details
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Rat, Cow
Immunogen
Synthetic peptide: C-SEDITRSANLTDQ, corresponding to internal sequence amino acids 198 - 210 of Human MEIS1 (NP_002389.1)
C-SEDITRSA NLTDQ
Positive control
Human Cerebral Cortex lysate
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
ab80593 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
Clonality
Polyclonal
Isotype
IgG
Research areas
Stem Cells >> Hematopoietic Progenitors >> Myeloid >> Myeloid Progenitor
Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> Developmental Families >> HOX
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Western blot - MEIS1 antibody (ab80593)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab80593 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
ELISA
Application notes
Peptide ELISA: antibody detection limit dilution 1/32000
WB: Use at a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 43 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.
Tissue specificity
Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum.
Involvement in disease
Defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7 (RLS7) [MIM:612853]. Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation.
Sequence similarities
Belongs to the TALE/MEIS homeobox family.
Contains 1 homeobox DNA-binding domain.
Cellular localization
Nucleus.
Target information above from: UniProt accessionO00470
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Meis1 myeloid ecotropic viral integration site 1 homolog mouse antibody
- Homeo box protein Meis1 antibody
- Homeobox protein Meis1 antibody
see all
Database links
- Entrez Gene: 613877 Cow
- Entrez Gene: 4211 Human
- Entrez Gene: 17268 Mouse
- Entrez Gene: 686117 Rat
- Omim: 601739 Human
- SwissProt: O00470 Human
- SwissProt: Q60954 Mouse
- Unigene: 526754 Human
see all
Anti-MEIS1 antibody images:
Western blot - MEIS1 antibody (ab80593)
Anti-MEIS1 antibody (ab80593) at 0.1 µg/ml + Human Cerebral Cortex lysate (in RIPA buffer) at 35 µg
Predicted band size : 43 kDa
Observed band size : 43 kDa
References for Anti-MEIS1 antibody (ab80593)
ab80593 has not yet been referenced specifically in any publications.
Publishing research using ab80593? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"