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Anti-MEIS1 antibody (ab80593)

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Overview

Product name

Anti-MEIS1 antibody
See all MEIS1 products (3) ...

Description

Goat polyclonal to MEIS1

Tested applications

WB, ELISAmore details

Cross reactivity

Reacts with

Human

Predicted to work with

Mouse, Rat, Cow

Immunogen

Synthetic peptide: C-SEDITRSANLTDQ, corresponding to internal sequence amino acids 198 - 210 of Human MEIS1 (NP_002389.1)

C-SEDITRSA NLTDQ

Positive control

Human Cerebral Cortex lysate

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, Tris buffered saline, pH 7.3

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Purification notes

ab80593 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Clonality

Polyclonal

Isotype

IgG

  • Western blot - MEIS1 antibody (ab80593)Western blot - MEIS1 antibody (ab80593) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab80593 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

Peptide ELISA: antibody detection limit dilution 1/32000
WB: Use at a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 43 kDa.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.

Tissue specificity

Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum.

Involvement in disease

Defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7 (RLS7) [MIM:612853]. Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation.

Sequence similarities

Belongs to the TALE/MEIS homeobox family.
Contains 1 homeobox DNA-binding domain.

Cellular localization

Nucleus.

Target information above from: UniProt accessionO00470 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Meis1 myeloid ecotropic viral integration site 1 homolog mouse antibody
  • Homeo box protein Meis1 antibody
  • Homeobox protein Meis1 antibody
  • Leukemogenic homolog protein antibody
  • MEIS 1 antibody
  • Meis homeo box 1 antibody
  • Meis homeobox 1 antibody
  • Meis1 antibody
  • Meis1 mouse homolog antibody
  • Meis1 myeloid ecotropic viral integration site 1 homolog antibody
  • MEIS1 protein antibody
  • MEIS1_HUMAN antibody
  • MGC43380 antibody
  • Myeloid ecotropic viral integration site 1 homolog antibody
  • WUGSC:H NH0444B04.1 antibody
see all

Anti-MEIS1 antibody images:

  Western blot - MEIS1 antibody (ab80593)

Western blot - MEIS1 antibody (ab80593)

Anti-MEIS1 antibody (ab80593) at 0.1 µg/ml + Human Cerebral Cortex lysate (in RIPA buffer) at 35 µg

Predicted band size : 43 kDa
Observed band size : 43 kDa

References for Anti-MEIS1 antibody (ab80593)

ab80593 has not yet been referenced specifically in any publications.

Publishing research using ab80593? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"