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Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab13866 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 45 kDa (predicted molecular weight: 48 kDa).

Target

  • FunctionCatalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases.
  • Involvement in diseaseDefects in MAP2K2 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.
  • Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications    MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1).
    Acetylation of Ser-222 and Ser-226 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.

    • Target information above from: UniProt accession P36507 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    see all
  • Alternative names
      Cardiofaciocutaneous syndrome antibodyCFC syndrome antibodyDual specificity mitogen activated protein kinase kinase 2 antibody
      Dual specificity mitogen-activated protein kinase kinase 2 antibodyERK activator kinase 2 antibodyFLJ26075 antibodyMAP kinase kinase 2 antibodyMAP2K 2 antibodymap2k2 antibodyMAPK / ERK kinase 2 antibodyMAPK/ERK kinase 2 antibodyMAPKK 2 antibodyMAPKK2 antibodyMEK 2 antibodyMEK2 antibodyMicrotubule Associated Protein Kinase Kinase 2 antibodyMitogen activated protein kinase kinase 2 antibodyMitogen activated protein kinase kinase 2 p45 antibodyMKK 2 antibodyMKK2 antibodyMP2K2_HUMAN antibodyOTTHUMP00000165826 antibodyOTTHUMP00000165827 antibodyPRKMK 2 antibodyPRKMK2 antibody
    see all

References for Anti-MEK2 antibody (ab13866)

ab13866 has not yet been referenced specifically in any publications.

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