Anti-MEK3 antibody [1D10] (ab117633)

Overview

• Product nameAnti-MEK3 antibody [1D10]See all MEK3 primary antibodies ...
• Description
  Mouse monoclonal [1D10] to MEK3
• Tested applicationsSandwich ELISA, WB, IHC-P more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Recombinant Human MEK3 protein.

• Positive controlHuman Placenta tissue.

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
• Storage bufferpH: 7.20
  Constituent: 99% PBS
• Concentration information loading...
• PurityProtein A purified
• Clonality Monoclonal
• Clone number1D10
• IsotypeIgG1
• Light chain typekappa
• Research Areas
  • Cancer
  • Signal transduction
  • Protein phosphorylation
  • Serine/threonine kinases
  • MAPK pathway

  • Signal Transduction
  • Protein Phosphorylation
  • Tyrosine Kinases
  • Other

  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Kinases
  • MAPK Pathway

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Other factors

  • Immunology
  • Innate Immunity
  • TLR Signaling

Applications

Target

• FunctionDual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.
• Tissue specificityAbundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
• Involvement in diseaseNote=Defects in MAP2K3 may be involved in colon cancer.
• Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
  Contains 1 protein kinase domain.
• Post-translational
  modificationsAutophosphorylated.
  Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity.
  Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.

Target information above from: UniProt accession P46734 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 5606 Human
  • Omim: 602315 Human
  • SwissProt: P46734 Human
  • Unigene: 514012 Human

• Alternative names
  dual specificity mitogen activated protein kinase kinase 3 antibodyDual specificity mitogen-activated protein kinase kinase 3 antibodyMAP kinase kinase 3 antibody

  map2k3 antibodyMAPK ERK kinase 3 antibodyMAPK/ERK kinase 3 antibodyMAPKK 3 antibodyMAPKK3 antibodyMEK 3 antibodyMEK3 antibodyMitogen activated protein kinase kinase 3 antibodyMKK 3 antibodyMKK3 antibodyMP2K3_HUMAN antibodyPRKMK 3 antibodyPRKMK3 antibodySAPK kinase 2 antibodySAPKK 2 antibodySAPKK2 antibodyStress activated protein kinase kinase 2 antibody

  see all

Anti-MEK3 antibody [1D10] images

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEK3 antibody [1D10] (ab117633)
  ab117633, at 5 µg/ml, staining MEK3 in Formalin-fixed, Paraffin-embedded Human placenta tissue by Immunohistochemistry.
• 

  Sandwich ELISA - Anti-MEK3 antibody [1D10] (ab117633)
  sELISA showing the detection limit for recombinant proprietary tagged MEK3 protein is approximately 0.03ng/ml as a capture antibody (ab117633).