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Overview

  • Product nameAnti-MEK7 (phospho S277 + T275) antibodySee all MEK7 primary antibodies ...
  • Description
    Rabbit polyclonal to MEK7 (phospho S277 + T275)
  • Tested applicationsICC/IF, WB more details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to amino acids surrounding Thr275/Ser277 of Human MEK7

Properties

Applications

Our Abpromise guarantee covers the use of ab78148 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ICC/IF ICC/IF: Use at an assay dependent concentration. PubMed: 23226105
WB WB: 1/1000. Predicted molecular weight: 47 kDa.

Target

  • FunctionStress activated, dual specificity kinase that activates the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.
  • Tissue specificityUbiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.
  • Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications    Activated by phosphorylation on Ser/Thr.
  • Cellular localizationNucleus. Cytoplasm.

    • Target information above from: UniProt accession O14733 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        c-Jun N-terminal kinase kinase 2 antibodyDual specificity mitogen activated protein kinase kinase 7 antibodyDual specificity mitogen-activated protein kinase kinase 7 antibody
        JNK activating kinase 2 antibodyJNK kinase 2 antibodyJNK-activating kinase 2 antibodyJnkk 2 antibodyJnkk-2 antibodyJnkk2 antibodyMAP kinase kinase 7 antibodyMAP2K7 antibodyMAPK/ERK kinase 7 antibodyMAPKK 7 antibodyMAPKK-7 antibodyMAPKK7 antibodyMEK 7 antibodyMitogen Activated Protein Kinase kinase 7 antibodyMKK 7 antibodyMKK-7 antibodyMKK7 antibodyMP2K7_HUMAN antibodyPRKMK 7 antibodyPRKMK-7 antibodyPRKMK7 antibodySek 2 antibodySek-2 antibodySek2 antibodySKK4 antibody
      see all

    Anti-MEK7 (phospho S277 + T275) antibody images

    • Western blot - MEK7 (phospho S277 + T275) antibody (ab78148)
      Western blot - MEK7 (phospho S277 + T275) antibody (ab78148)
      All lanes : Anti-MEK7 (phospho S277 + T275) antibody (ab78148) at 1/1000 dilution

      Lane 1 : Recombinant tagged MEK7ß1, untreated
      Lane 2 : Recombinant tagged MEK7ß1, phosphorylated by MEKK1

      Secondary
      Goat anti-Rabbit HRP-conjugated at 1/5000 dilution

      Predicted band size : 47 kDa
      Observed band size : 73 kDa (why is the actual band size different from the predicted?)

    References for Anti-MEK7 (phospho S277 + T275) antibody (ab78148)

    This product has been referenced in:
    • Feltrin D  et al. Growth cone MKK7 mRNA targeting regulates MAP1b-dependent microtubule bundling to control neurite elongation. PLoS Biol 10:e1001439 (2012). WB, ICC/IF ; Mouse . Read more (PubMed: 23226105) »

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