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Product Name
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MHC Class I H2 Kd antibody [1.B.548]
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See all MHC Class I H2 Kd antibodies (8)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [1.B.548] to MHC Class I H2 Kd
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Immunogen
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Full length MHC Class I H2 Kd protein (Mouse)
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Reacts with
(species key)
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Ms
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Specificity
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ab62226 detects classical mouse MHC class I antigen, H2 Kd allele.
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Tested applications
(see key)
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Flow Cyt, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions Flow Cyt: Use 1µg for 106 cells. WB: Use at an assay dependent dilution. Predicted molecular weight: 42 kDa.
Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cell Membrane
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Research areas
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Immunology >> Adaptive Immunity >> MHC >> Class I
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Relevance
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MHC Class I H2 Kd is involved in the presentation of foreign antigens to the immune system. The “classical” MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant Beta2-microglobulin. These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. MHC Class I antigens expressed on thymic epithelial cells regulate the positive and negative selection of CD8+ T cells during T cell ontogeny.
MHC Class I H2 Kd is present on 100% of T-cells and B-cells including beta cells of Langerhans, etc. It is also present on endothelial and epithelial tissue.
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Database links
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The links below go to external sites and will open in a new browser window
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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1.B.548
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Isotype
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IgG2b
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Light chain type
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kappa
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Purity
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Protein G purified
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Storage buffer
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Preservative: 0.09% Sodium Azide Constituents: 1.0% BSA, PBS, pH 7.2 Material safety datasheet (MSDS) for this product: Sodium Azide MSDS
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Form
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Liquid
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Concentration
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0.500 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this MHC Class I H2 Kd antibody [1.B.548] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to MHC Class I H2 Kd
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