Anti-MIIP antibody (ab103380)

Overview

• Product nameAnti-MIIP antibodySee all MIIP primary antibodies ...
• Description
  Rabbit polyclonal to MIIP
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 280-320 of Human MIIP

• Positive controlZR-75-1 cell lysate.

Properties

• FormLiquid
• Storage instructionsStore at 4°C (up to 6 months). For long term storage store at -20°C
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesab103380 is purified through a protein A column, followed by peptide affinity purification.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cancer
  • Invasion/microenvironment
  • ECM
  • Cell adhesion
  • Other

  • Neuroscience
  • Cell Adhesion Proteins
  • Membrane Proteins

  • Neuroscience
  • Cell Adhesion Proteins
  • Cytoskeletal Proteins
  • Regulation

Applications

Target

• RelevanceMIIP has 3 SEG (segments of low compositional complexity) domains, an RGD motif, and several potential phosphorylation sites. The C-terminal region of IGFBP2 interacts with a central 44-amino acid sequence of MIIP. MIIP inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. It exhibits opposing effects to IGFBP2 on cell invasion. There are 2 named isoforms due to alternative splicing. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells. Isoform 2 is degraded by the ubiquitin-proteasome pathway.
• Database links
  • Entrez Gene: 60672 Human
  • Entrez Gene: 60672 Human
  • Omim: 608772 Human
  • SwissProt: Q5JXC2 Human
  • SwissProt: Q5JXC2 Human
  • Unigene: 8595 Human

• Alternative names
  FLJ12438 antibodyFLJ38609 antibodyIGFBP 2 binding protein antibody

  IGFBP2 binding protein antibodyIIP45 antibodyInvasion inhibitory protein 45 antibodyMigration and invasion inhibitory protein antibodyRP5 1077B9.4 antibody

  see all

Anti-MIIP antibody images

• 

  Western blot - MIIP antibody (ab103380)
  Anti-MIIP antibody (ab103380) at 1/100 dilution + ZR-75-1 cell lysate at 35 µg
  
  Predicted band size : 43 kDa