Overview
- Product nameAnti-MMP10 antibodySee all MMP10 primary antibodies ...
- DescriptionRabbit polyclonal to MMP10
- SpecificityDetects endogenous levels of total MMP10 protein.
- Tested applicationsICC/IF, ELISA, Flow Cyt, IHC-Fr more details
- Species reactivityReacts with: Mouse, Rat, Human
- Immunogen
Synthetic peptide (Human) from an internal region of MMP10.
- Positive controlHepG2 cells.
Properties
- FormLiquid
- Storage instructionsStore at -20°C. Stable for 12 months at -20°C
- Storage bufferPreservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4 -
Concentration information loading... - PurityImmunogen affinity purified
- Purification notesAffinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen
- Clonality Polyclonal
- IsotypeIgG
- Research Areas
Applications
Our Abpromise guarantee covers the use of ab59437 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| ICC/IF | ICC/IF: 1/500 - 1/1000. |
| ELISA | ELISA: 1/10000. |
| Flow Cyt | Flow Cyt: Use at an assay dependent dilution. PubMed: 21133852 |
| IHC-Fr | IHC-Fr: Use at an assay dependent dilution. PubMed: 21133852 |
Target
- FunctionCan degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.
- Sequence similaritiesBelongs to the peptidase M10A family.
Contains 4 hemopexin-like domains. - DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
- Cellular localizationSecreted > extracellular space > extracellular matrix.
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Database links
- Entrez Gene: 4319 Human
- Entrez Gene: 4319 Human
- Entrez Gene: 4319 Human
- Entrez Gene: 17384 Mouse
- Entrez Gene: 117061 Rat
- Omim: 185260 Human
- SwissProt: P09238 Human
- SwissProt: P09238 Human
- SwissProt: P09238 Human
- SwissProt: O55123 Mouse
- SwissProt: P07152 Rat
- Unigene: 2258 Human
- Unigene: 14126 Mouse
- Unigene: 9946 Rat
see all
Target information above from: UniProt accession
P09238
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010)
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Alternative names
- Matrix metalloproteinase 10 antibodyMatrix metalloproteinase-10 antibodyMMP 10 antibody
- MMP-10 antibodyMmp10 antibodyMMP10_HUMAN antibodySL 2 antibodySL-2 antibodySL2 antibodySTMY 2 antibodySTMY2 antibodyStromelysin 2 antibodyStromelysin II antibodyStromelysin-2 antibodyStromelysin2 antibodyStromelysinII antibodyTransin 2 antibodyTransin-2 antibodyTransin2 antibody
see all
Anti-MMP10 antibody images
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Immunocytochemistry/ Immunofluorescence - MMP10 antibody (ab59437)Immunofluorescent analysis of MMP10 in HepG2 cells with ab59437 (1/500 dilution); in the presence or absence of immunizing peptide.
References for Anti-MMP10 antibody (ab59437)
This product has been referenced in:
- Clark RT et al. T cell production of matrix metalloproteases and inhibition of parasite clearance by TIMP-1 during chronic Toxoplasma infection in the brain. ASN Neuro : (2010). Flow Cyt, IHC-Fr ; Mouse . Read more (PubMed: 21133852) »
