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MMP11 peptide (Carboxyterminal end) (ab44850)

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Overview

  • Product nameMMP11 peptide (Carboxyterminal end)See all MMP11 proteins and peptides ...
  • Protein descriptionThis peptide was used as an immunogen for ab38932 - MMP11 antibody - Carboxyterminal end.

    • Properties

  • Purity> 95 % by SDS-PAGE
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab44850 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    ELISA
    WB
  • Application notesELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. This peptide can be used with studies using ab38932. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        Matrix Metalloproteinase 11Matrix metalloproteinase-11MM11
        MMP 11MMP-11Mmp11MMP11_HUMANSL 3SL-3SL3ST 3ST3STMY 3STMY3Stromelysin 3Stromelysin 3 precursorStromelysin IIIStromelysin-3Stromelysin3StromelysinIII
      see all
  • FunctionMay play an important role in the progression of epithelial malignancies.
  • Tissue specificitySpecifically expressed in stromal cells of breast carcinomas.
  • Sequence similaritiesBelongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications    The precursor is cleaved by a furin endopeptidase.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.

    • Target information above from: UniProt accession P24347 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for MMP11 peptide (Carboxyterminal end) (ab44850)

    ab44850 has not yet been referenced specifically in any publications.

    Publishing research using ab44850 ? Please let us know so that we can cite the reference in this datasheet

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"