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Overview

  • Product nameMMP11 protein (Human)See all MMP11 proteins and peptides ...
  • Protein descriptionFull length Human MMP11 protein (purified from stimulated human fibroblasts) and supplied as a mixture of zymogen and processed (cleaved)forms.
  • Expression hostNative

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Purification notesThis protein is free of contaminating MMPs or TIMPs.
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 50% Glycerol, 0.02% Brij 35, 5mM Calcium chloride, 100mM Sodium chloride, 10mM Tris HCl, pH 7.4
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab39310 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB WB: Use at an assay dependent dilution. Detects a band of approximately 60,50 kDa. 60 kDa (Zymogen) and 50 kDa (processed form). Dilution optimised using Chromogenic detection.
    ELISA ELISA: Use at an assay dependent dilution.
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        Matrix Metalloproteinase 11Matrix Metalloproteinase 11Matrix metalloproteinase-11
        MM11MM11MMP 11MMP-11Mmp11MMP11_HUMANSL 3SL-3SL3ST 3ST3ST3STMY 3STMY3STMY3Stromelysin 3Stromelysin 3Stromelysin 3 precursorStromelysin 3 precursorStromelysin IIIStromelysin-3Stromelysin3StromelysinIII
      see all
  • FunctionMay play an important role in the progression of epithelial malignancies.
  • Tissue specificitySpecifically expressed in stromal cells of breast carcinomas.
  • Sequence similaritiesBelongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications    The precursor is cleaved by a furin endopeptidase.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.

    • Target information above from: UniProt accession P24347 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for MMP11 protein (Human) (ab39310)

    ab39310 has not yet been referenced specifically in any publications.

    Publishing research using ab39310 ? Please let us know so that we can cite the reference in this datasheet

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    Does this enzyme require activation via Furin or some other activation process for screening substrate candidates? If so is there a procedure available?

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    The product ab39310, full length Human MMP11 protein (purified from stimulated human fibroblasts) is supplied as a mixture of zymogen and processed (cleaved) forms. I am unaware of any procedure to activate the MMP11 p...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"