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Overview

  • Product nameMMP2 peptideSee all MMP2 proteins and peptides ...
  • Protein descriptionSynthetic peptide derived from within residues 500 - 600 of Human MMP2.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab83173 - MMP2 antibody.
  • Protein length660 amino acids

    • Properties

  • Purity70 - 90% by HPLC
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferInformation available upon request.
  • Concentration information loading...
  • Research Areas

    • Applications

  • Application notesThis peptide can be used with studies using ab83173.

    • Protein info

    • Alternative names
        72 kDa gelatinase72kD type IV collagenaseCLG 4
        CLG 4ACLG4CLG4ACollagenase Type 4 alphaCollagenase type IV AGelatinase AGelatinase alphaGelatinase neutrophilMatrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenaseMatrix Metalloproteinase 2Matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)Matrix metalloproteinase IIMatrix metalloproteinase-2MMP 2MMP IIMMP-2MMP2MMP2_HUMANMONANeutrophil gelatinasePEXTBE 1TBE-1
      see all
  • FunctionUbiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-
    -Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro.
    PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.
  • Tissue specificityProduced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate.
  • Involvement in diseaseDefects in MMP2 are the cause of Torg-Winchester syndrome (TWS) [MIM:259600]; also known as multicentric osteolysis nodulosis and arthropathy (MONA). TWS is an autosomal recessive osteolysis syndrome. It is severe with generalized osteolysis and osteopenia. Subcutaneous nodules are usually absent. Torg-Winchester syndrome has been associated with a number of additional features including coarse face, corneal opacities, patches of thickened, hyperpigmented skin, hypertrichosis and gum hypertrophy. However, these features are not always present and have occasionally been observed in other osteolysis syndromes.
  • Sequence similaritiesBelongs to the peptidase M10A family.
    Contains 3 fibronectin type-II domains.
    Contains 4 hemopexin-like domains.
  • DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications    Phosphorylation on multiple sites modulates enzymatic activity. Phosphorylated by PKC in vitro.
    The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT-MMP3). Autocatalytic cleavage in the C-terminal produces the anti-angiogenic peptide, PEX. This processing appears to be facilitated by binding integrinv/beta3.
  • Cellular localizationSecreted > extracellular space > extracellular matrix. Membrane. Nucleus. Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes.

    • Target information above from: UniProt accession P08253 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for MMP2 peptide (ab92853)

    ab92853 has not yet been referenced specifically in any publications.

    Publishing research using ab92853 ? Please let us know so that we can cite the reference in this datasheet

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    Submit an Abreview for ab92853 Submit a Question for ab92853

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    I know that the sequence information is proprietary and is not available. I need the C-termianl domain of MMP-2 (aa from 400 to 660). Do you have some peptide or recombinant protein that have these necessary requirements and characteristics?
    Thank for...

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    Thank you for contacting us.

    We can supply the following informaiton.

    The ab44848 epitope is at the aminoterminus of the Hemopexin-like domain, and the ab41042 epitope is at the carboxyterminal end of the Hemopexin-like domain. The two e...

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    I know that the sequence information is proprietary and is not available. I need the C-termianl domain of MMP-2 (aa from 400 to 660). Do you have some peptide or recombinant protein that have these necessary requirements and characteristics?
    Thank for...

    Read More

    Thank you for contacting us.

    I have requested broader sequence information from laboratory. I will send you the details soon.

    Many thanks for having patience!

    I would like to have some information about the products: ab44848; ab92853 and ab41042. I need to know the exact sequence of each of the peptides and if these products are regularly in production and suitable.
    Thank you for your help.

    Thank you for contacting us.

    These peptides are used to produce the relative antibodies so unfortunately the sequence information is proprietary and is not available. I am sorry I will not be very helpful in this case. However if you have any o...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"