MMP2 peptide (ab92853)
- 72 kDa gelatinase72kD type IV collagenaseCLG 4
- CLG 4ACLG4CLG4ACollagenase Type 4 alphaCollagenase type IV AGelatinase AGelatinase alphaGelatinase neutrophilMatrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenaseMatrix Metalloproteinase 2Matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)Matrix metalloproteinase IIMatrix metalloproteinase-2MMP 2MMP IIMMP-2MMP2MMP2_HUMANMONANeutrophil gelatinasePEXTBE 1TBE-1
-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro.
PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.
Contains 3 fibronectin type-II domains.
Contains 4 hemopexin-like domains.
modificationsPhosphorylation on multiple sites modulates enzymatic activity. Phosphorylated by PKC in vitro.
The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT-MMP3). Autocatalytic cleavage in the C-terminal produces the anti-angiogenic peptide, PEX. This processing appears to be facilitated by binding integrinv/beta3.
References for MMP2 peptide (ab92853)
ab92853 has not yet been referenced specifically in any publications.