Overview

  • Product nameAnti-MMP3 antibody [SL-1 IID4] (Biotin)See all MMP3 primary antibodies ...
  • Description
    Mouse monoclonal [SL-1 IID4] to MMP3 (Biotin)
  • ConjugationBiotin
  • SpecificityReacts with both pro- and active form of MMP3.
  • Tested applicationsWB, ICC/IF more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    APMA (4-Aminophenylmercuric acetate)-activated Human MMP3

  • Positive control
    • Conditioned, serum-free medium from TPA-treated Human endometrial cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab79674 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
AP
ICC/IF
  • Application notesAP: Use at an assay dependent dilution.
    ICC/IF: Use at an assay dependent dilution.
    WB: Use at a concentration of 0.5 - 1.0 µg/ml for 2hrs at RT. Predicted molecular weight: 54 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionCan degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
    • Sequence similaritiesBelongs to the peptidase M10A family.
      Contains 4 hemopexin-like domains.
    • DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    • Cellular localizationSecreted > extracellular space > extracellular matrix.
    • Target information above from: UniProt accession P08254 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
    • Alternative names
      • CHDS6 antibody
      • Matrix metalloproteinase 3 antibody
      • Matrix metalloproteinase 3 preproprotein antibody
      • Matrix metalloproteinase-3 antibody
      • MGC126102 antibody
      • MGC126103 antibody
      • MGC126104 antibody
      • MMP 3 antibody
      • MMP-3 antibody
      • MMP3 antibody
      • MMP3_HUMAN antibody
      • Progelatinase antibody
      • Proteoglycanase antibody
      • SL 1 antibody
      • SL-1 antibody
      • SL1 antibody
      • STMY antibody
      • STMY1 antibody
      • STR1 antibody
      • Stromelisin 1 antibody
      • Stromelysin 1 antibody
      • Stromelysin 1 progelatinase antibody
      • Stromelysin-1 antibody
      • Transin 1 antibody
      • Transin-1 antibody
      see all

    References for Anti-MMP3 antibody [SL-1 IID4] (Biotin) (ab79674)

    This product has been referenced in:
    • Galazka G  et al. APMA (4-aminophenylmercuric acetate) activation of stromelysin-1 involves protein interactions in addition to those with cysteine-75 in the propeptide. Biochemistry 35:11221-7 (1996). WB, AP ; Human . Read more (PubMed: 8780527) »

    See 1 Publication for this product

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