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Product Name
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MMP3 antibody
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See all MMP3 antibodies (23)...
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Product type
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Primary antibodies
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Description
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Sheep polyclonal to MMP3
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Immunogen
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ProMMP-3 purified from cultured human rheumatoid synovial fibroblasts, shown to be homogeneous by SDS-PAGE.
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Reacts with
(species key)
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Hu
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Specificity
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Identity has been confirmed by Western blot and by double diffusion (Ouchterlony), against human MMP3 and a known anti-human MMP3.
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Tested applications
(see key)
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
This product is suitable for use in Western blotting. It has been evaluated using reducing conditions and a 10-20% SDS gel. Thefollowing dilutions should be used as guidelines for determining those appropriate for the users system.
Antigen: 50ng MMP-3
Primary Antibody: 1/1000
Suitability for use in immunohistochemical procedures and enzyme-linked immunosorbent assays has not been assessed but use insuch assays should not necessarily be excluded.
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Cellular localization
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Secreted; extracellular matrix
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Research areas
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Cardiovascular >> Atherosclerosis >> Thrombosis >> Other
Cancer >> Tumor biomarkers >> Enzymes >> MMPs
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Metalloprotease >> MMPs
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> MMPs
Cancer >> Invasion/microenvironment >> Angiogenesis >> ECM enzymes >> MMPs
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> MMP
Cardiovascular >> Angiogenesis >> Adhesion / ECM >> Matrix Metalloproteinases >> MMP
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Relevance
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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP3 is an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. MMP3 is reported to be implicated in rheumatoid arthritis and some forms of cancer.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Sheep
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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IgG fraction
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Storage buffer
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Glycine buffered saline pH7.4, 0.1% Sodium Azide, 0.1% EACA, 0.01% Benzamidine,1mM EDTA Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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17.500 mg/ml
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Storage instructions
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Store at +4°C.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this MMP3 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to MMP3
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MMP3 antibody - more information
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Customer reviews (feedback) regarding MMP3 antibody |
Customer FAQs regarding MMP3 antibody |
Protocols for MMP3 antibody |
Price and availability of products related to MMP3 antibody |
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Contact Abcam with a Technical Enquiry about MMP3 antibody |
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