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Read our guarantee »Products:Cardiovascular >> Angiogenesis >> Adhesion / ECM >> Matrix Metalloproteinases >> MMP
Anti-MMP3 antibody
See all MMP3 products (22) ...
Sheep polyclonal to MMP3
Identity has been confirmed by Western blot and by double diffusion (Ouchterlony), against human MMP3 and a known anti-human MMP3.
Reacts with
Human
ProMMP-3 purified from cultured human rheumatoid synovial fibroblasts, shown to be homogeneous by SDS-PAGE.
Liquid
Store at +4°C.
Glycine buffered saline pH7.4, 0.1% Sodium Azide, 0.1% EACA, 0.01% Benzamidine,1mM EDTA
Concentration information loading...
IgG fraction
Polyclonal
IgG
Cardiovascular >> Atherosclerosis >> Thrombosis >> Other
Cancer >> Tumor biomarkers >> Enzymes >> MMPs
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Metalloprotease >> MMPs
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> MMPs
Cancer >> Invasion/microenvironment >> Angiogenesis >> ECM enzymes >> MMPs
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> MMP
Cardiovascular >> Angiogenesis >> Adhesion / ECM >> Matrix Metalloproteinases >> MMP
Our Abpromise guarantee covers the use of ab8482 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
This product is suitable for use in Western blotting. It has been evaluated using reducing conditions and a 10-20% SDS gel. Thefollowing dilutions should be used as guidelines for determining those appropriate for the users system.
Antigen: 50ng MMP-3
Primary Antibody: 1/1000
Suitability for use in immunohistochemical procedures and enzyme-linked immunosorbent assays has not been assessed but use insuch assays should not necessarily be excluded.
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
Belongs to the peptidase M10A family.
Contains 4 hemopexin-like domains.
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Secreted > extracellular space > extracellular matrix.
Target information above from: UniProt accessionP08254
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
ab8482 has not yet been referenced specifically in any publications.
Publishing research using ab8482? Please let us know so that we can cite the reference in this datasheet
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