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Overview

  • Product nameMMP3 protein (Human)See all MMP3 proteins and peptides ...
  • Protein descriptionFull length native protein (purified) of Human MMP3.This Protein was used as an immunogen for ab38912 - MMP3 antibody - Whole molecule.
  • Expression hostNative

    • Properties

  • Purification notesThis protein purified from human fibroblast is free of endogenous inhibitors, TIMP1 and TIMP2, and other matrix metalloproteinases.
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferThe enzyme is supplied as a mixture of the zymogen and active enzyme in:
    Preservative: 0.01% Sodium Azide
    Constituents: 50% Glycerol, 0.025% Brij 35, 5mM Calcium chloride, 250mM Sodium chloride, 25mM Tris, pH 7.4
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab39306 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Enzyme Immunoassay - Control EIA-Ctrl: Use at an assay dependent dilution.
    WB WB: Use at an assay dependent dilution. The zymogen runs as 59 and 57 kDa bands, representing the glycosylated and non-glycosylated forms. Active enzyme runs at 45 kDa, and breaks down stepwise to a 28 kDa form. The enzyme is supplied as a mixture of the zymogen and active enzyme.
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.
  • Application notesThis peptide can be used with studies using ab38912,ab137659 and ab137678.

    • Protein info

    • Alternative names
        CHDS6Matrix metalloproteinase 3Matrix metalloproteinase 3 preproprotein
        Matrix metalloproteinase-3MGC126102MGC126103MGC126104MMP 3MMP-3MMP3MMP3_HUMANProgelatinaseProteoglycanaseSL 1SL-1SL1STMYSTMY1STR1Stromelisin 1Stromelysin 1Stromelysin 1 progelatinaseStromelysin-1Transin 1Transin-1
      see all
  • FunctionCan degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
  • Sequence similaritiesBelongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.

    • Target information above from: UniProt accession P08254 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    MMP3 protein (Human) images

    References for MMP3 protein (Human) (ab39306)

    ab39306 has not yet been referenced specifically in any publications.

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