![- MMP7 antibody [SPM294], prediluted (ab17854) image](#ab17854_1.jpg)
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Product name
Anti-MMP7 antibody [SPM294], prediluted
See all MMP7 products (12) ...
Description
Mouse monoclonal [SPM294] to MMP7, prediluted
Tested applications
IHC-Pmore details
Cross reactivity
Reacts with
Human
Immunogen
Recombinant human matrilysin (MMP7/PUMP1).
Positive control
Conditioned, serum-free medium from TPA treated human Endometrial cells. Placenta. Bladder, breast, ovarian carcinomas.
General notes
Molecular weight: ~28kDa (pro form) and ~18kDa (active form).
Properties
Form
Prediluted
Storage instructions
Store at +4°C.
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Monoclonal
Clone number
SPM294
Isotype
IgG2b
Light chain type
kappa
Research areas
Cancer >> Tumor biomarkers >> Enzymes >> MMPs
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Metalloprotease >> MMPs
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> MMPs
Cancer >> Invasion/microenvironment >> Angiogenesis >> ECM enzymes >> MMPs
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> MMP
Cardiovascular >> Angiogenesis >> Adhesion / ECM >> Matrix Metalloproteinases >> MMP
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- MMP7 antibody [SPM294], prediluted (ab17854)
![- MMP7 antibody [SPM294], prediluted (ab17854) image](/ps/datasheet/Images/17/ab17854/ab17854_1.jpg)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab17854 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: Use at an assay dependent dilution.
Target
Function
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
Sequence similarities
Belongs to the peptidase M10A family.
Domain
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Cellular localization
Secreted > extracellular space > extracellular matrix.
Target information above from: UniProt accessionP09237
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Matrilysin antibody
- Matrilysin uterine antibody
- Matrin antibody
see all
Database links
- Entrez Gene: 4316 Human
- Omim: 178990 Human
- SwissProt: P09237 Human
- Unigene: 2256 Human
Anti-MMP7 antibody [SPM294], prediluted images:
- MMP7 antibody [SPM294], prediluted (ab17854)
ab17854 MMP7/Matrilysin/PUMP1 staining in formalin-fixed human placenta (30min incubation at RT).
References for Anti-MMP7 antibody [SPM294], prediluted (ab17854)
ab17854 has not yet been referenced specifically in any publications.
Publishing research using ab17854? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"