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Overview

  • Product nameMMP8 peptide (Propeptide domain)See all MMP8 proteins and peptides ...
  • Protein descriptionSynthetic peptide MMP8. (Note: the amino acid sequence is proprietary) This peptide was used as an immunogen for ab38988 - MMP8 antibody - Propeptide domain.

    • Properties

  • Purity> 95 % by SDS-PAGE
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab41066 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    ELISA
    WB
  • Application notesELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. This peptide can be used with studies using ab38988. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        CLG 1CLG1Collagenase 1
        Collagenase 1 NeutrophilHNCMatrix metallopeptidase 8 (neutrophil collagenase)Matrix Metalloprotease 8Matrix metalloproteinase-8MMP 8MMP-8Mmp8MMP8_HUMANNeutrophil collagenasePMNL CLPMNL collagenasePMNL-CLPMNLCL
      see all
  • FunctionCan degrade fibrillar type I, II, and III collagens.
  • Tissue specificityNeutrophils.
  • Sequence similaritiesBelongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Cellular localizationCytoplasmic granule. Secreted > extracellular space > extracellular matrix. Stored in intracellular granules.

    • Target information above from: UniProt accession P22894 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for MMP8 peptide (Propeptide domain) (ab41066)

    ab41066 has not yet been referenced specifically in any publications.

    Publishing research using ab41066 ? Please let us know so that we can cite the reference in this datasheet

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