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MMP9 peptide (Carboxyterminal end) (ab41067)

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Overview

  • Product nameMMP9 peptide (Carboxyterminal end)See all MMP9 proteins and peptides ...
  • Protein descriptionSynthetic peptide MMP9. (Note: the amino acid sequence for this peptide is not available) This peptide was used as an immunogen for ab38906 - MMP9 antibody - Carboxyterminal end.

    • Properties

  • Purity> 95 % by SDS-PAGE
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab41067 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    ELISA
    WB
  • Application notesELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. This peptide can be used with studies using ab38906. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        82 kDa matrix metalloproteinase-992 kDa gelatinase92 kDa type IV collagenase
        CLG 4BCLG 4BCLG4BCollagenase Type 4 betaCollagenase Type 4 betaCollagenase type IV 92 KDCollagenase type IV 92 KDEC 3.4.24.35Gelatinase 92 KDGelatinase 92 KDGelatinase BGelatinase betaGelatinase betaGelatinaseBGELBGELBMacrophage gelatinaseMacrophage gelatinaseMANDP2Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)Matrix Metalloproteinase 9Matrix Metalloproteinase 9MMP 9MMP-9MMP9MMP9_HUMANType V collagenaseType V collagenase
      see all
  • FunctionMay play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-
    -Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
  • Tissue specificityProduced by normal alveolar macrophages and granulocytes.
  • Involvement in diseaseIntervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Metaphyseal anadysplasia 2 (MANDP2) [MIM:613073]: A bone development disorder characterized by skeletal anomalies that resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similaritiesBelongs to the peptidase M10A family.
    Contains 3 fibronectin type-II domains.
    Contains 4 hemopexin-like domains.
  • DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications    Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.
    N- and O-glycosylated.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.

    • Target information above from: UniProt accession P14780 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for MMP9 peptide (Carboxyterminal end) (ab41067)

    ab41067 has not yet been referenced specifically in any publications.

    Publishing research using ab41067 ? Please let us know so that we can cite the reference in this datasheet

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    Submit an Abreview for ab41067 Submit a Question for ab41067

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    10
    Votes: Highest First

    Dear technical team,

    Our customer needs MMP9 protein active and inactive form.

    I have searched MMP9 but couldn't get information about active and inactive form.

    Let me know, please.


    Best regards,
    Youn...

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    Thank you once again for your enquiries regarding our MMP9 proteins.

    To follow up, I now have further information regarding the following proteins:

    ab39308 MMP9 protein (Human)
    ab39309 MMP9 protein (Mouse)
    ab41067 MMP9 pept...

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    Dear Sir or Madam, could you please provide us more information about your product "MMP9 peptide (Carboxyterminal end) (ab41067)"? I do not need that exact sequence, but could you please tell us how much of the C-terminal of MMP9 is included oe what is th...

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    Vielen Dank für Ihre Anfrage. Bitte entschuldigen Sie, dass die Antwort so lange auf sich warten ließ. Ich hatte das Labor, das das MMP9-Peptid ab41067 herstellt, kontaktiert und musste sehr lange auf eine zufriedenstellende Antwort warten. Ich kann...

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    Please send the protein sequence for MMP9 peptide (Carboxyterminal end) (ab41067) - we have had success with whole molecule polyclonals to MMP-9 with zebrafish embryos, and would like to try a C-terminal specific antibody. But comparing the sequence used...

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    Thank you for your enquiry. The overall homology between human and zebrafish MMP-9 is 57%, and the homology in the region of the P1-MMP-9 peptide is only 52%. Unfortunately, information about the exact amino acid sequence of this product is proprietary...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"