Recombinant Anti-MORC3 antibody [EPR10113(B)] (ab150398)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR10113(B)] to MORC3
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
Overview
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Product name
Anti-MORC3 antibody [EPR10113(B)]
See all MORC3 primary antibodies -
Description
Rabbit monoclonal [EPR10113(B)] to MORC3 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details
Unsuitable for: ICC/IF,IHC-P or IP -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide within Human MORC3 aa 900-1000 (C terminal). The exact sequence is proprietary.
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Positive control
- Human skeletal muscle and fetal heart lysates.
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General notes
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20ºC. -
Storage buffer
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading...
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Purity
Tissue culture supernatant -
Clonality
Monoclonal -
Clone number
EPR10113(B) -
Isotype
IgG -
Research areas
Associated products
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Alternative Versions
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab150398 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/1000 - 1/10000. Predicted molecular weight: 107 kDa.
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Notes |
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WB
1/1000 - 1/10000. Predicted molecular weight: 107 kDa. |
Target
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Function
Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233). -
Tissue specificity
Expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney. -
Sequence similarities
Contains 1 CW-type zinc finger. -
Post-translational
modificationsSumoylation is involved in interaction with PML and localization to PML nuclear bodies. -
Cellular localization
Nucleus, nucleoplasm. Nucleus matrix. Nucleus, PML body. Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent. - Information by UniProt
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Database links
- Entrez Gene: 23515 Human
- Entrez Gene: 338467 Mouse
- Entrez Gene: 304074 Rat
- Omim: 610078 Human
- SwissProt: Q14149 Human
- SwissProt: F7BJB9 Mouse
- Unigene: 421150 Human
- Unigene: 287329 Mouse
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Alternative names
- KIAA0136 antibody
- Microrchidia 3 antibody
- MORC family CW type zinc finger 3 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab150398 has been referenced in 1 publication.
- Wang L et al. Calcinosis and malignancy are rare in Chinese adult patients with myositis and nuclear matrix protein 2 antibodies identified by an unlabeled immunoprecipitation assay. Clin Rheumatol 37:2731-2739 (2018). PubMed: 30039266