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- Proteins and Peptides
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Product name
Anti-MTBP antibody
See all MTBP products (3) ...
Description
Rabbit polyclonal to MTBP
Tested applications
WB, ICC/IFmore details
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide: GAVECFEEEDSNSRESLS, corresponding to amino acids 122-139 of Human MTBP which differ from the mouse sequence by three amino acids.
GAVECFEEEDSNSRESLS
Positive control
K562 cell lysate.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
PBS with 0.02% sodium azide
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Cell cycle >> Cell cycle inhibitors >> Other
Epigenetics and Nuclear Signaling >> Cell cycle >> Cell Cycle Inhibitors >> Other
Cell Biology >> Cell Cycle >> Cell Cycle Inhibitors >> Other
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Western blot - MTBP antibody (ab8107)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab8107 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 99 kDa.
ICC/IF: Use a concentration of 5 µg/ml.
Target
Relevance
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2 and MTBP, were recently discovered. The transcriptional activity of p53 is modulated by post translational regulation of the p53 protein including stabilization and acetylation. P53 transcriptionally activates MDM2 gene then the translated MDM2 protein binds to p53 and promotes the degradation of p53 leading to lowering the concentration of p53 protein. MDM2 inhibits both p53 mediated G1 arrest and apoptosis. A recently discovered protein termed MTBP was found to bind to MDM2 and to inhibit the modulation effect of MDM2 on p53. MTBP is expressed in a variety of normal tissues.
Alternative names
- MDM 2 BP antibody
- MDM2 (mouse double minute 2) binding protein 104kD antibody
- MDM2 (mouse double minute 2) binding protein antibody
see all
Database links
- Entrez Gene: 27085 Human
- Omim: 605927 Human
- SwissProt: Q96DY7 Human
- Unigene: 186433 Human
- Unigene: 46701 Human
Anti-MTBP antibody images:
Western blot - MTBP antibody (ab8107)
Anti-MTBP antibody (ab8107) at 1 µg/ml + K562 whole cell lysate
Predicted band size : 99 kDa
References for Anti-MTBP antibody (ab8107)
ab8107 has not yet been referenced specifically in any publications.
Publishing research using ab8107? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"