Anti-MTCO1 antibody [1D6E1A8] - Mitochondrial Marker (ab14705)

ab14705 has been referenced in 78 publications.

1. Strub GM et al. Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. FASEB J 25:600-12 (2011). PubMed: 20959514
2. Getz J et al. The cardiac copper chaperone proteins Sco1 and CCS are up-regulated, but Cox 1 and Cox4 are down-regulated, by copper deficiency. Biol Trace Elem Res 143:368-77 (2011). PubMed: 20878365
3. Misiak M et al. Brain region-specific vulnerability of astrocytes in response to 3-nitropropionic acid is mediated by cytochrome c oxidase isoform expression. Cell Tissue Res 341:83-93 (2010). PubMed: 20602186
4. Brys K et al. Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans. BMC Biol 8:91 (2010). PubMed: 20584279
5. Kotarsky H et al. Characterization of complex III deficiency and liver dysfunction in GRACILE syndrome caused by a BCS1L mutation. Mitochondrion 10:497-509 (2010). PubMed: 20580947
6. Safdar A et al. Aberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adults. PLoS One 5:e10778 (2010). PubMed: 20520725
7. Crawford SA et al. Naturally occurring R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)gamma(3) results in increased oxidative capacity and glucose uptake in human primary myotubes. Diabetologia 53:1986-97 (2010). PubMed: 20473479
8. Patel BP et al. Caloric restriction shortens lifespan through an increase in lipid peroxidation, inflammation and apoptosis in the G93A mouse, an animal model of ALS. PLoS One 5:e9386 (2010). PubMed: 20195368
9. Nadanaciva S et al. High-content screening for compounds that affect mtDNA-encoded protein levels in eukaryotic cells. J Biomol Screen 15:937-48 (2010). PubMed: 20625181
10. Perkins GA et al. The micro-architecture of mitochondria at active zones: electron tomography reveals novel anchoring scaffolds and cristae structured for high-rate metabolism. J Neurosci 30:1015-26 (2010). PubMed: 20089910
11. Khalimonchuk O et al. Formation of the redox cofactor centers during Cox1 maturation in yeast cytochrome oxidase. Mol Cell Biol 30:1004-17 (2010). PubMed: 19995914
12. López-Royuela N et al. Bim is the key mediator of glucocorticoid-induced apoptosis and of its potentiation by rapamycin in human myeloma cells. Biochim Biophys Acta 1803:311-22 (2010). PubMed: 19914305
13. Levéen P et al. The GRACILE mutation introduced into Bcs1l causes postnatal complex III deficiency: A viable mouse model for mitochondrial hepatopathy. Hepatology : (2010). PubMed: 21190281
14. Suthammarak W et al. Mutations in mitochondrial complex III uniquely affect complex I in Caenorhabditis elegans. J Biol Chem 285:40724-31 (2010). PubMed: 20971856
15. Beck Jørgensen S et al. Reduced AMP-activated protein kinase activity in mouse skeletal muscle does not exacerbate the development of insulin resistance with obesity. Diabetologia 52:2395-404 (2009). PubMed: 19688337
16. Perez-Martinez X et al. Dual functions of Mss51 couple synthesis of Cox1 to assembly of cytochrome c oxidase in Saccharomyces cerevisiae mitochondria. Mol Biol Cell 20:4371-80 (2009). PubMed: 19710419
17. Gómez LA et al. Supercomplexes of the mitochondrial electron transport chain decline in the aging rat heart. Arch Biochem Biophys 490:30-5 (2009). PubMed: 19679098
18. Rackham O et al. Pentatricopeptide repeat domain protein 1 lowers the levels of mitochondrial leucine tRNAs in cells. Nucleic Acids Res 37:5859-67 (2009). PubMed: 19651879
19. Lin KH et al. Mechanisms of resveratrol-induced platelet apoptosis. Cardiovasc Res 83:575-85 (2009). PubMed: 19423619
20. Oswald C et al. Knockdown of human COX17 affects assembly and supramolecular organization of cytochrome c oxidase. J Mol Biol 389:470-9 (2009). PubMed: 19393246
21. Lastra G et al. Direct renin inhibition improves systemic insulin resistance and skeletal muscle glucose transport in a transgenic rodent model of tissue renin overexpression. Endocrinology 150:2561-8 (2009). PubMed: 19246535
22. Hanein S et al. TMEM126A, encoding a mitochondrial protein, is mutated in autosomal-recessive nonsyndromic optic atrophy. Am J Hum Genet 84:493-8 (2009). PubMed: 19327736
23. Nadanaciva S et al. Lateral-flow immunoassay for detecting drug-induced inhibition of mitochondrial DNA replication and mtDNA-encoded protein synthesis. J Immunol Methods 343:1-12 (2009). PubMed: 19152798
24. Tang T et al. hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis. J Biol Chem 284:5414-24 (2009). PubMed: 19103604
25. Vempati UD et al. Lack of cytochrome c in mouse fibroblasts disrupts assembly/stability of respiratory complexes I and IV. J Biol Chem 284:4383-91 (2009). PubMed: 19075019
26. Alves E et al. Acetyl-L-carnitine provides effective in vivo neuroprotection over 3,4-methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain. Neuroscience 158:514-23 (2009). PubMed: 19015003
27. Song H & Sokolov M Analysis of protein expression and compartmentalization in retinal neurons using serial tangential sectioning of the retina. J Proteome Res 8:346-51 (2009). PubMed: 19049346
28. Suarez J et al. Alterations in mitochondrial function and cytosolic calcium induced by hyperglycemia are restored by mitochondrial transcription factor A in cardiomyocytes. Am J Physiol Cell Physiol 295:C1561-8 (2008). PubMed: 19060297
29. Habibi J et al. Renin inhibition attenuates insulin resistance, oxidative stress, and pancreatic remodeling in the transgenic Ren2 rat. Endocrinology 149:5643-53 (2008). PubMed: 18653711
30. Greiss S et al. C. elegans SIR-2.1 translocation is linked to a proapoptotic pathway parallel to cep-1/p53 during DNA damage-induced apoptosis. Genes Dev 22:2831-42 (2008). PubMed: 18923081
31. Rorbach J et al. The human mitochondrial ribosome recycling factor is essential for cell viability. Nucleic Acids Res 36:5787-99 (2008). PubMed: 18782833
32. Natoli R et al. Expression and role of the early-response gene Oxr1 in the hyperoxia-challenged mouse retina. Invest Ophthalmol Vis Sci 49:4561-7 (2008). PubMed: 18539939
33. Jones FS et al. Caffeine stimulates cytochrome oxidase expression and activity in the striatum in a sexually dimorphic manner. Mol Pharmacol 74:673-84 (2008). PubMed: 18583456
34. Mabalirajan U et al. Mitochondrial structural changes and dysfunction are associated with experimental allergic asthma. J Immunol 181:3540-8 (2008). PubMed: 18714027
35. Lynn EG et al. SIRT2 is a negative regulator of anoxia-reoxygenation tolerance via regulation of 14-3-3 zeta and BAD in H9c2 cells. FEBS Lett 582:2857-62 (2008). PubMed: 18640115
36. Pagel-Langenickel I et al. PGC-1alpha integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscle. J Biol Chem 283:22464-72 (2008). PubMed: 18579525
37. Putignani L et al. Alteration of expression levels of the oxidative phosphorylation system (OXPHOS) in breast cancer cell mitochondria. Breast Cancer Res Treat 110:439-52 (2008). PubMed: 17899367
38. Pierrel F et al. Coa2 is an assembly factor for yeast cytochrome c oxidase biogenesis that facilitates the maturation of Cox1. Mol Cell Biol 28:4927-39 (2008). PubMed: 18541668
39. Genova ML et al. Is supercomplex organization of the respiratory chain required for optimal electron transfer activity? Biochim Biophys Acta 1777:740-6 (2008). PubMed: 18454935
40. Johnson WT & Anderson CM Cardiac cytochrome C oxidase activity and contents of subunits 1 and 4 are altered in offspring by low prenatal copper intake by rat dams. J Nutr 138:1269-73 (2008). PubMed: 18567746
41. Whaley-Connell A et al. Effect of renin inhibition and AT1R blockade on myocardial remodeling in the transgenic Ren2 rat. Am J Physiol Endocrinol Metab 295:E103-9 (2008). PubMed: 18460596
42. Yu Q et al. Differential loss of cytochrome-c oxidase subunits in ischemia-reperfusion injury: exacerbation of COI subunit loss by PKC-epsilon inhibition. Am J Physiol Heart Circ Physiol 294:H2637-45 (2008). PubMed: 18408135
43. Son M et al. Isolated cytochrome c oxidase deficiency in G93A SOD1 mice overexpressing CCS protein. J Biol Chem 283:12267-75 (2008). PubMed: 18334481
44. Bastin J et al. Activation of peroxisome proliferator-activated receptor pathway stimulates the mitochondrial respiratory chain and can correct deficiencies in patients' cells lacking its components. J Clin Endocrinol Metab 93:1433-41 (2008). PubMed: 18211970
45. Devi L et al. Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain. J Biol Chem 283:9089-100 (2008). PubMed: 18245082
46. Zielonka J et al. Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: identification of homo- and heterodimers. Free Radic Biol Med 44:835-46 (2008). PubMed: 18155177
47. Desquiret V et al. Mitochondrial effects of dexamethasone imply both membrane and cytosolic-initiated pathways in HepG2 cells. Int J Biochem Cell Biol 40:1629-41 (2008). PubMed: 18243040
48. Baden KN et al. Early developmental pathology due to cytochrome c oxidase deficiency is revealed by a new zebrafish model. J Biol Chem 282:34839-49 (2007). PubMed: 17761683
49. Jha P et al. Crucial role of apoptosis in the resolution of experimental autoimmune anterior uveitis. Invest Ophthalmol Vis Sci 48:5091-100 (2007). PubMed: 17962461
50. Hawkins BJ et al. G protein-coupled receptor Ca2+-linked mitochondrial reactive oxygen species are essential for endothelial/leukocyte adherence. Mol Cell Biol 27:7582-93 (2007). PubMed: 17724077
51. Margineantu DH et al. Hsp90 inhibition decreases mitochondrial protein turnover. PLoS One 2:e1066 (2007). PubMed: 17957250
52. Pierrel F et al. Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly. EMBO J 26:4335-46 (2007). PubMed: 17882260
53. Rea SL et al. Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. PLoS Biol 5:e259 (2007). PubMed: 17914900
54. Pravenec M et al. Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains. Genome Res 17:1319-26 (2007). PubMed: 17693571
55. Song H et al. Compartment-specific phosphorylation of phosducin in rods underlies adaptation to various levels of illumination. J Biol Chem 282:23613-21 (2007). PubMed: 17569665
56. Li Y et al. An assembled complex IV maintains the stability and activity of complex I in mammalian mitochondria. J Biol Chem 282:17557-62 (2007). PubMed: 17452320
57. Park JS et al. Yeast NDI1 improves oxidative phosphorylation capacity and increases protection against oxidative stress and cell death in cells carrying a Leber's hereditary optic neuropathy mutation. Biochim Biophys Acta 1772:533-42 (2007). PubMed: 17320357
58. Ventura N & Rea SL Caenorhabditis elegans mitochondrial mutants as an investigative tool to study human neurodegenerative diseases associated with mitochondrial dysfunction. Biotechnol J 2:584-95 (2007). PubMed: 17443764
59. Scheper GC et al. Mitochondrial aspartyl-tRNA synthetase deficiency causes leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation. Nat Genet 39:534-9 (2007). PubMed: 17384640
60. Jung ME et al. Ethanol withdrawal posttranslationally decreases the activity of cytochrome c oxidase in an estrogen reversible manner. Neurosci Lett 416:160-4 (2007). PubMed: 17320290
61. Dell'agnello C et al. Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice. Hum Mol Genet 16:431-44 (2007). PubMed: 17210671
62. Boesze-Battaglia K et al. The tetraspanin protein peripherin-2 forms a complex with melanoregulin, a putative membrane fusion regulator. Biochemistry 46:1256-72 (2007). PubMed: 17260955
63. Callahan LA & Supinski GS Diaphragm and cardiac mitochondrial creatine kinases are impaired in sepsis. J Appl Physiol 102:44-53 (2007). PubMed: 16916915
64. Li Y et al. Cytochrome c oxidase subunit IV is essential for assembly and respiratory function of the enzyme complex. J Bioenerg Biomembr 38:283-91 (2006). PubMed: 17091399
65. Wang Y & Bogenhagen DF Human mitochondrial DNA nucleoids are linked to protein folding machinery and metabolic enzymes at the mitochondrial inner membrane. J Biol Chem 281:25791-802 (2006). PubMed: 16825194
66. Sundaram P et al. ATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegans. Mol Biol Cell 17:3678-88 (2006). PubMed: 16723499
67. Pye D et al. Production of transmitochondrial cybrids containing naturally occurring pathogenic mtDNA variants. Nucleic Acids Res 34:e95 (2006). PubMed: 16885236
68. Grad LI & Lemire BD Riboflavin enhances the assembly of mitochondrial cytochrome c oxidase in C. elegans NADH-ubiquinone oxidoreductase mutants. Biochim Biophys Acta 1757:115-22 (2006). PubMed: 16443191
69. Ogilvie I et al. A molecular chaperone for mitochondrial complex I assembly is mutated in a progressive encephalopathy. J Clin Invest 115:2784-92 (2005). PubMed: 16200211
70. Ogborn DI et al. Effects of creatine and exercise on skeletal muscle of FRG1-transgenic mice. Can J Neurol Sci 39:225-31 (2012). WB; Mouse. PubMed: 22343158
71. Frier BC et al. Reductions in RIP140 are not required for exercise- and AICAR-mediated increases in skeletal muscle mitochondrial content. J Appl Physiol 111:688-95 (2011). WB; Rat. PubMed: 21700896
72. Cameron JM et al. Mutations in Iron-Sulfur Cluster Scaffold Genes NFU1 and BOLA3 Cause a Fatal Deficiency of Multiple Respiratory Chain and 2-Oxoacid Dehydrogenase Enzymes. Am J Hum Genet 89:486-95 (2011). WB; Caenorhabditis elegans. PubMed: 21944046
73. Escobar-Alvarez S et al. Inhibition of human peptide deformylase disrupts mitochondrial function. Mol Cell Biol 30:5099-109 (2010). WB; Human. PubMed: 20805355
74. Iwasaki R et al. Catechin, green tea component, causes caspase-independent necrosis-like cell death in chronic myelogenous leukemia. Cancer Sci 100:349-56 (2009). ICC/IF; Human. PubMed: 19200260
75. Zech T et al. Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling. EMBO J 28:466-76 (2009). WB; Human. PubMed: 19177148
76. Piao L et al. Association of LETM1 and MRPL36 contributes to the regulation of mitochondrial ATP production and necrotic cell death. Cancer Res 69:3397-404 (2009). WB; Human. PubMed: 19318571
77. Susini L et al. TCTP protects from apoptotic cell death by antagonizing bax function. Cell Death Differ : (2008). PubMed: 18274553
78. Ramachandran A et al. Chronic exposure to nitric oxide alters the free iron pool in endothelial cells: role of mitochondrial respiratory complexes and heat shock proteins. Proc Natl Acad Sci U S A 101:384-9 (2004). PubMed: 14691259