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Read our guarantee »Products:Tags & Cell Markers >> Cell Type Markers >> Tumor Associated
Anti-MUC16 antibody
See all MUC16 products (15) ...
Rabbit polyclonal to MUC16
IHC-Pmore details
Reacts with
Human
Synthetic peptide derived from the C terminal region of Human MUC16
Colon carcinoma tissue
Liquid
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.02% Sodium Azide
Constituents: 2% BSA, PBS, pH 7.2
Concentration information loading...
Immunogen affinity purified
Polyclonal
IgG
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> MUC
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Proteins >> MUC
Tags & Cell Markers >> Cell Type Markers >> Tumor Associated
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MUC16 antibody (ab89365)
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Our Abpromise guarantee covers the use of ab89365 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: 1/50 - 1/200.
Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas.
Contains 2 ANK repeats.
Contains 56 SEA domains.
Composed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing more than 60 partially conserved tandem repeats of 156 amino acids each (AAs 12061-21862) and a C-terminal transmembrane contain domain with a short cytoplasmic tail.
Heavily O-glycosylated; expresses both type 1 and type 2 core glycans.
Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans.
May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space.
May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.
Cell membrane. Secreted > extracellular space. May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.
Target information above from: UniProt accessionQ8WXI7
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MUC16 antibody (ab89365)

Left panel: ab89365 at 1/100 dilution staining MUC16 in formalin-fixed, paraffin-embedded Human colon carcinoma tissue by immunohistochemistry .
Right panel: same, after pre-treatment with the immunizing peptide.
ab89365 has not yet been referenced specifically in any publications.
Publishing research using ab89365? Please let us know so that we can cite the reference in this datasheet
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Left panel: ab89365 at 1/100 dilution staining MUC16 in formalin-fixed, paraffin-embedded Human colon carcinoma tissue by immunohistochemistry .
Right panel: same, after pre-treatment with the immunizing peptide.
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