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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MUC16 antibody (ab89365)
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Product Name
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MUC16 antibody
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See all MUC16 antibodies (12)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to MUC16
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Immunogen
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Synthetic peptide derived from the C terminal region of Human MUC16
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Reacts with
(species key)
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Hu
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Tested applications
(see key)
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IHC-P
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-P: 1/50 - 1/200.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Colon carcinoma tissue
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Cellular localization
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Cell membrane; Single pass type I membrane protein. Secreted, extracellular space. Note May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.
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Research areas
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Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> MUC
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Proteins >> MUC
Tags & Cell Markers >> Cell Type Markers >> Tumor Associated
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Relevance
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MUC16 (CA125) is a serum marker that is used routinely in gynecologic practice to monitor patients with ovarian cancer. It is a mullerian duct differentiation antigen that is overexpressed in epithelial ovarian cancer cells and secreted into the blood, although its expression is not entirely confined to ovarian cancer. Most biochemical studies have concluded that MUC16 is a high molecular mass glycoprotein, although estimates of its size range from 200 to 2000 kDa with smaller “subunits” being described by some investigators.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: 0.02% Sodium Azide
Constituents: 2% BSA, PBS, pH 7.2 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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0.500 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this MUC16 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for MUC16 antibody images, references, products related to ab89365 and other tools.
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MUC16 antibody images:
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 Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MUC16 antibody (ab89365)
Left panel: ab89365 at 1/100 dilution staining MUC16 in formalin-fixed, paraffin-embedded Human colon carcinoma tissue by immunohistochemistry .
Right panel: same, after pre-treatment with the immunizing peptide.
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Search PubMed (MEDLINE) for references to MUC16
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MUC16 antibody - more information
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Customer reviews (feedback) regarding MUC16 antibody |
Customer FAQs regarding MUC16 antibody |
Protocols for MUC16 antibody |
Price and availability of products related to MUC16 antibody |
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MUC16 antibody - related products:
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MUC16 antibody - other tools:
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Contact Abcam with a Technical Enquiry about MUC16 antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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