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Anti-Macrophage Inflammatory Protein 1 beta antibody (Biotin) (ab84439)

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Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab84439 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
ELISA
Sandwich ELISA
  • Application notesELISA: Use at a concentration of 0.25 - 1 µg/ml. Detection limit for recombinant Human protein: 0.2 - 0.4 ng/well, using 100 µl/well antibody solution.
    sELISA: Use at a concentration of 0.25 - 1 µg/ml. Detection limit for recombinant Human protein: 0.2 - 0.4 ng/well, using 100 µl/well antibody solution.
    WB: Use at a concentration of 0.1 - 0.2 µg/ml. Detection limit for recombinant Human protein: 1.5 - 3.0 ng/lane, under reducing or non-reducing conditions. Predicted molecular weight: 10 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionMonokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
    • Sequence similaritiesBelongs to the intercrine beta (chemokine CC) family.
    • Post-translational
      modifications      N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.
    • Cellular localizationSecreted.

      • Target information above from: UniProt accession P13236 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      see all
    • Alternative names
        MIP 1 beta antibody Secreted protein G 26 antibodyACT 2 antibody
        ACT-2 antibodyACT2 antibodyAT744.1 antibodyAT744.2 antibodyC C motif chemokine 4 antibodyC C motif chemokine 4 like antibodyCC chemokine ligand 4 antibodyCC chemokine ligand 4L1d2 antibodyCC chemokine ligand 4L2 antibodyCCL4 antibodyCCL4_HUMAN antibodyccl4l 1 antibodyCCL4L antibodyCCL4L1 antibodyChemokine (C C motif) ligand 4 antibodyChemokine (C C motif) ligand 4 like 1 antibodyChemokine (C C motif) ligand 4 like 1, telomeric antibodyChemokine (C C motif) ligand 4 like 2 antibodyChemokine CC Motif Ligand 4 antibodyG 26 antibodyG 26 T lymphocyte secreted protein antibodyG-26 T-lymphocyte-secreted protein antibodyHC21 antibodylag 1 antibodyLAG-1 antibodyLAG1 antibodyLymphocyte activation gene 1 antibodyLymphocyte activation gene 1 protein antibodyMacrophage inflammatory protein 1 beta antibodyMacrophage inflammatory protein 1-beta antibodyMacrophage inflammatory protein 1b2 antibodyMGC104418 antibodyMGC126025 antibodyMGC126026 antibodyMIP-1-beta antibodyMIP-1-beta(1-69) antibodyMIP-1-beta(3-69) antibodyMIP1 beta antibodyMIP1B antibodyMIP1B1 antibodyMonocyte adherence induced protein 5 alpha antibodyPAT 744 antibodyProtein H400 antibodySCYA2 antibodySCYA4 antibodySCYA4L antibodySecreted protein G26 antibodySIS gamma antibodySIS-gamma antibodySmall inducible cytokine A4 (homologous to mouse Mip 1b) antibodySmall inducible cytokine A4 antibodySmall-inducible cytokine A4 antibodyT cell activation protein 2 antibodyT-cell activation protein 2 antibody
      see all

    References for Anti-Macrophage Inflammatory Protein 1 beta antibody (Biotin) (ab84439)

    ab84439 has not yet been referenced specifically in any publications.

    Publishing research using ab84439 ? Please let us know so that we can cite the reference in this datasheet

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