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Anti-Macrophage Inflammatory Protein 1 beta antibody (HRP) (ab106028)

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Overview

  • Product nameAnti-Macrophage Inflammatory Protein 1 beta antibody (HRP)See all Macrophage Inflammatory Protein 1 beta primary antibodies ...
  • Description
    Rabbit polyclonal to Macrophage Inflammatory Protein 1 beta (HRP)
  • ConjugationHRP
  • Specificityab106028 will recognize both native and recombinant Human IL9 in cell supernatants and certain body fluids.
  • Tested applicationsWB, ELISA more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein of Human Macrophage Inflammatory Protein 1 beta.

Properties

  • FormLiquid
  • Storage instructionsStore at +4°C or -20°C long term. Avoid repeated freeze / thaw cycles. Store undiluted.
  • Storage bufferpH: 7.20
    Preservative: 0.01% Gentamicin sulphate
    Constituents: 0.27% Potassium phosphate, 0.88% Sodium chloride, 1% BSA
    Note: Do NOT add Sodium Azide!
  • Concentration information loading...
  • PurityIon Exchange Chromatography
  • Purification notesab106028 is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated. This antibody has been heated to 56°C for 30 minutes.
  • Clonality Polyclonal
  • IsotypeIgG
  • Research Areas

Applications

Our Abpromise guarantee covers the use of ab106028 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use at an assay dependent dilution. Detects a band of approximately 15 kDa (predicted molecular weight: 10 kDa).
ELISA ELISA: Use at an assay dependent dilution.

Target

  • FunctionMonokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
  • Sequence similaritiesBelongs to the intercrine beta (chemokine CC) family.
  • Post-translational
    modifications    N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession P13236 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    see all
  • Alternative names
      MIP 1 beta antibody Secreted protein G 26 antibodyACT 2 antibody
      ACT-2 antibodyACT2 antibodyAT744.1 antibodyAT744.2 antibodyC C motif chemokine 4 antibodyC C motif chemokine 4 like antibodyCC chemokine ligand 4 antibodyCC chemokine ligand 4L1d2 antibodyCC chemokine ligand 4L2 antibodyCCL4 antibodyCCL4_HUMAN antibodyccl4l 1 antibodyCCL4L antibodyCCL4L1 antibodyChemokine (C C motif) ligand 4 antibodyChemokine (C C motif) ligand 4 like 1 antibodyChemokine (C C motif) ligand 4 like 1, telomeric antibodyChemokine (C C motif) ligand 4 like 2 antibodyChemokine CC Motif Ligand 4 antibodyG 26 antibodyG 26 T lymphocyte secreted protein antibodyG-26 T-lymphocyte-secreted protein antibodyHC21 antibodyLAG 1 antibodyLAG-1 antibodyLAG1 antibodyLymphocyte activation gene 1 antibodyLymphocyte activation gene 1 protein antibodyMacrophage inflammatory protein 1 beta antibodyMacrophage inflammatory protein 1-beta antibodyMacrophage inflammatory protein 1b2 antibodyMGC104418 antibodyMGC126025 antibodyMGC126026 antibodyMIP 1 beta antibodyMIP-1-beta antibodyMIP-1-beta(1-69) antibodyMIP-1-beta(3-69) antibodyMIP1 beta antibodyMIP1B antibodyMIP1B1 antibodyMonocyte adherence induced protein 5 alpha antibodyPAT 744 antibodyProtein H400 antibodySCYA2 antibodySCYA4 antibodySCYA4L antibodySecreted protein G 26 antibodySecreted protein G26 antibodySIS gamma antibodySIS-gamma antibodySmall inducible cytokine A4 (homologous to mouse Mip 1b) antibodySmall inducible cytokine A4 antibodySmall-inducible cytokine A4 antibodyT cell activation protein 2 antibodyT-cell activation protein 2 antibody
    see all

References for Anti-Macrophage Inflammatory Protein 1 beta antibody (HRP) (ab106028)

ab106028 has not yet been referenced specifically in any publications.

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