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Products:Immunology >> Innate Immunity >> Macrophage / Inflamm.
Overview
Product name
Macrophage Inflammatory Protein 3 beta protein
See all Macrophage Inflammatory Protein 3 beta products (3) ...
Protein description
Highly pure (>98%) recombinant human Macrophage Inflammatory Protein 3 beta.
Expression host
E. coli
Properties
Purification notes
Sterile filtered Greater than 99% pure by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per µg (1EU/µg).
Form
Lyophilised
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Concentration
Concentration information loading...
Additional notes
The biological activity of this product was determined by its ability to chemoattract human T cells using a concentration of 10.0-50.0 ng/ml.
Sequence notes
Human MIP-3-beta is an 8.8 kDa protein containing 77 amino acid residues: GTNDAED CCL SVTQKPIPGY IVRNFHYLLI KDGCRVPAVV FTTLRGRQLC APPDQPWVER IIQRLQRTSA KMKRRSS
Research areas
Immunology >> Innate Immunity >> Chemokines >> Beta Chemokines (CC)
Immunology >> Innate Immunity >> Macrophage / Inflamm.
Applications
Show applications key
Our Abpromise guarantee covers the use of ab9832 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
SDS-PAGE: Use at an assay dependent dilution.
FuncS: Use at an assay dependent dilution.
Protein info
Relevance
MIP3 chemokines are among many novel beta chemokines recently identified through bioinformatics in the Expressed Sequence Tag (EST) database. They are distantly related to other beta chemokines (20-30% aa sequence homology). MIP3 chemokines are useful probes for studying the biology of inflammation and cell migration. Their expression is strongly up-regulated by inflammatory signals and down-regulated by the anti-inflammatory cytokine IL10. MIP3 beta is also known as ELC (EBI1-1 ligand chemokine) and is constitutively expressed in various lymphoid tissues (thymus, lymph nodes, appendix and spleen). MIP3 beta is a chemoattractant for cultured human lymphocytes, dendritic cells, human T lymphoblastoid CEM NKR2 and hemopoietic progenitor cells. It may be involved in G Protein activation in human NK cells. MIP3 beta is a unique functional ligand for CCR7. The MIP3 beta gene has been mapped to chormosome 9p13.
Cellular localization
Secreted
References for Macrophage Inflammatory Protein 3 beta protein (ab9832)
ab9832 has not yet been referenced specifically in any publications.
Publishing research using ab9832? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"