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Mannose 6 Phosphate Receptor (Cation dependent) protein (His tag) (ab80157)

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Overview

Product name

Mannose 6 Phosphate Receptor (Cation dependent) protein (His tag)

Protein description

Recombinant fragment: MFPFYSCWRT GLLLLLLAVA VRESWQTEEK TCDLVGEKGK ESEKELALVK RLKPLFNKSF, corresponding to N terminal amino acids 1-60 of Human Mannose 6 Phosphate Receptor (Cation dependent) fused to a His tag, 12kDa (SwissProt ID P20645).

Expression host

E. coli

Properties

Purification notes

Purity: > 90%

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: PBS

Concentration

Concentration information loading...

Sequence

MFPFYSCWRT GLLLLLLAVA VRESWQTEEK TCDLVGEKGK ESEKELALVK RLKPLFNKSF

Research areas

Tags & Cell Markers >> Subcellular Markers >> Organelles >> Lysosome
Immunology >> Innate Immunity >> Macrophage / Inflamm.

  • SDS-PAGE - Mannose 6 Phosphate Receptor (Cation dependent) protein (His tag) (ab80157)SDS-PAGE - Mannose 6 Phosphate Receptor (Cation dependent) protein (His tag) (ab80157) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab80157 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Protein info

Relevance

Mannose 6 Phosphate Receptor (Cation dependent) transports phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

Cellular localization

Lysosome membrane; Single-pass type I membrane protein.

Mannose 6 Phosphate Receptor (Cation dependent) protein (His tag) images:

  SDS-PAGE - Mannose 6 Phosphate Receptor (Cation dependent) protein (His tag) (ab80157)

SDS-PAGE - Mannose 6 Phosphate Receptor (Cation dependent) protein (His tag) (ab80157)

20% SDS PAGE showing ab80157 at approximately 12 kDa.

References for Mannose 6 Phosphate Receptor (Cation dependent) protein (His tag) (ab80157)

ab80157 has not yet been referenced specifically in any publications.

Publishing research using ab80157? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"