Anti-Mannose 6 Phosphate Receptor (Cation independent) antibody (ab61774)

Overview

• Product nameAnti-Mannose 6 Phosphate Receptor (Cation independent) antibodySee all Mannose 6 Phosphate Receptor (Cation independent) primary antibodies ...
• Description
  Rabbit polyclonal to Mannose 6 Phosphate Receptor (Cation independent)
• Specificityab61774 detects endogenous levels of total Mannose 6 Phosphate Receptor (Cation independent) protein.
• Tested applicationsIHC-P, ELISA, ICC/IF more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse
• Immunogen

  Synthetic non-phosphopeptide derived from human Mannose 6 Phosphate Receptor (Cation independent) around the phosphorylation site of serine 2484 (D-D-S-D-E).

• Positive controlHuman lung carcinoma tissue, 293 cell extracts and HeLa cells.

Properties

• FormLiquid
• Storage instructionsStore at -20°C. Stable for 12 months at -20°C
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: 50% Glycerol, PBS (without Mg²⁺ and Ca²⁺), 150mM Sodium chloride, pH 7.4
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Signal Transduction
  • Protein Trafficking
  • Golgi Proteins

  • Tags & Cell Markers
  • Subcellular Markers
  • Organelles
  • Endosome

  • Immunology
  • Innate Immunity
  • Macrophage / Inflamm.

Applications

Target

• FunctionTransport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
• Sequence similaritiesBelongs to the MRL1/IGF2R family.
  Contains 1 fibronectin type-II domain.
• DomainContains 15 repeating units of approximately 147 AA. The most highly conserved region within the repeat consists of a stretch of 13 AA that contains cysteines at both ends.
• Cellular localizationLysosome membrane. Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.

Target information above from: UniProt accession P11717 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 3482 Human
  • Entrez Gene: 16004 Mouse
  • Omim: 147280 Human
  • SwissProt: P11717 Human
  • SwissProt: Q07113 Mouse
  • Unigene: 487062 Human
  • Unigene: 26553 Mouse

• Alternative names
  300 kDa mannose 6 phosphate receptor antibody300 kDa mannose 6-phosphate receptor antibodyCation independent mannose 6 phosphate receptor antibody

  Cation-independent mannose-6-phosphate receptor antibodyCD222 antibodyCD222 antigen antibodyCI Man 6 P receptor antibodyCI Man-6-P receptor antibodyCI MPR antibodyCI-MPR antibodyCIMPR antibodyIGF 2 receptor antibodyIGF 2R antibodyIGF II receptor antibodyIGF-II receptor antibodyIGF2 receptor antibodyIGF2R antibodyInsulin like growth factor 2 receptor antibodyInsulin like growth factor II receptor antibodyInsulin-like growth factor 2 receptor antibodyInsulin-like growth factor II receptor antibodyM6P R antibodyM6P/IGF2 receptor antibodyM6P/IGF2R antibodyM6PR antibodyMPR 300 antibodyMPR300 antibodyMPRI antibodyMPRI_HUMAN antibody

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Anti-Mannose 6 Phosphate Receptor (Cation independent) antibody images

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  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Mannose 6 Phosphate Receptor (Cation independent) antibody (ab61774)
  ab61774 at 1/50 - 1/100 dilution staining Mannose 6 Phosphate (Cation independent) in human lung carcinoma by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.
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  Immunocytochemistry/ Immunofluorescence - Mannose 6 Phosphate Receptor (Cation independent) antibody (ab61774)
  ab61774 at 1/500 - 1/1000 dilution staining Mannose 6 Phosphate Receptor (Cation independent) in HeLa cells by Immunofluorescence, in the absence or presence of the immunising peptide.