Overview

  • Product name
    Manzamine A
  • Description
    β-carboline alkaloid. GSK-3β inhibitor.
  • Biological description
    β-carboline alkaloid. GSK-3β inhibitor. Inhibits growth of rodent malaria parasite in vivo. Inhibits autophagy in pancreatic cancer cells. Orally active. Antimalarial, neuroprotective and anticancer agent. Active in vivo and in vitro.

Properties

  • Molecular weight
    548.76
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C36H44N4O
  • CAS Number
    104196-68-1
  • PubChem identifier
    14727313
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    O[C@@]16CCC=CCCCCN8CC[C@@H](C(=C1)c3nccc2c4ccccc4nc23)[C@]7(CC5C=CCCCCN5[C@@H]67)C8
  • Source

    Xestospongia ashmorica

References

This product has been referenced in:
  • Kallifatidis G  et al. The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Mar Drugs 11:3500-16 (2013). Read more (PubMed: 24048269) »
  • Hamann M  et al. Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease. J Nat Prod 70:1397-405 (2007). Read more (PubMed: 17708655) »
  • Ang KK  et al. In vivo antimalarial activity of the beta-carboline alkaloid manzamine A. Antimicrob Agents Chemother 44:1645-9 (2000). Read more (PubMed: 10817722) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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