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Overview
Product name
Anti-Matrin 3 antibody
See all Matrin 3 products (5) ...
Description
Rabbit polyclonal to Matrin 3
Tested applications
WB, IHC-Pmore details
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Rat, Cow
Immunogen
A region within synthetic peptide: MSKSFQQSSL SRDSQGHGRD LSAAGIGLLA AATQSLSMPA SLGRMNQGTA, corresponding to N terminal amino acids 1-50 of Human Matrin 3
MSKSFQQSSL SRDSQGHGRD LSAAGIGLLA AATQSLSMPA SLGRMNQGTA
Positive control
Jurkat cell lysate, Human heart tissue.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 2% Sucrose, PBS
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Polyclonal
Isotype
IgG
Applications
Show applications key
Our Abpromise guarantee covers the use of ab51081 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1.25 µg/mlDetects a band of approximately 95 kDa (predicted molecular weight: 95 kDa).
IHC-P: Use a concentration of 4 - 8 µg/ml.
Target
Function
May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs.
Involvement in disease
Defects in MATR3 are the cause of myopathy distal type 2 (MPD2) [MIM:606070]; also called vocal cord and pharyngeal dysfunction with distal myopathy (VCPDM). MPD2 is a muscular disorder characterized by distal weakness, with onset in hands and feet, associated with vocal cord and pharyngeal weakness causing a nasal voice and swallowing disorders.
Sequence similarities
Contains 1 matrin-type zinc finger.
Contains 2 RRM (RNA recognition motif) domains.
Cellular localization
Nucleus matrix.
Target information above from: UniProt accessionP43243
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- MATR3 antibody
- MATR3_HUMAN antibody
- Matrin-3 antibody
- Matrin3 antibody
Database links
- Entrez Gene: 9782 Human
- Entrez Gene: 17184 Mouse
- Entrez Gene: 29150 Rat
- Omim: 164015 Human
- SwissProt: P43243 Human
- SwissProt: Q3TTX0 Mouse
- SwissProt: Q4FJT0 Mouse
- SwissProt: Q5BL18 Mouse
see all
Anti-Matrin 3 antibody images:
Western blot - Matrin 3 antibody (ab51081)
Anti-Matrin 3 antibody (ab51081) at 1.25 µg + Jurkat cell lysate at 10 µg
Secondary
HRP conjugated anti-Rabbit IgG at 1/50000 dilution
Predicted band size : 95 kDa
Observed band size : 95 kDa
Immunohistochemistry (Paraffin-embedded sections) - Matrin 3 antibody (ab51081)
Ab51081 at 8µg/ml staining myocardial cells of paraffin embedded human heart tissue.
Immunohistochemistry (Paraffin-embedded sections) - Matrin 3 antibody (ab51081)
Ab51081 at 8µg/ml staining paraffin embedded human skeletal muscle cells.
References for Anti-Matrin 3 antibody (ab51081)
ab51081 has not yet been referenced specifically in any publications.
Publishing research using ab51081? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"