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Anti-Matrin 3 antibody (ab70336)

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Overview

Product name

Anti-Matrin 3 antibody
See all Matrin 3 products (5) ...

Description

Rabbit polyclonal to Matrin 3

Tested applications

IPmore details

Cross reactivity

Reacts with

Mouse, Human, Xenopus laevis

Immunogen

Synthetic peptide corresponding to a region between residues 475 and 500 of human Matrin 3 (NP_061322.2)

Positive control

HeLa whole cell lysate.

Properties

Form

Liquid

Storage instructions

Store at +4°C.

Storage buffer

Preservative: 0.09% Sodium Azide
Constituents: 8mM PBS, 60mM Citrate, 150mM Tris, pH 7-8

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Purification notes

ab70336 was affinity purified using an epitope specific to Matrin 3 immobilized on solid support.

Clonality

Polyclonal

Isotype

IgG

Research areas

Epigenetics and Nuclear Signaling >> Chromatin Binding Proteins >> DNA / RNA binding
Epigenetics and Nuclear Signaling >> Chromosome Structure >> Scaffold Proteins

  • Immunoprecipitation - Anti-Matrin 3 antibody (ab70336)Immunoprecipitation - Anti-Matrin 3 antibody (ab70336) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab70336 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

IP: Use at 1-4µg/mg of lysate.

Is unsuitable for WB.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs.

Involvement in disease

Defects in MATR3 are the cause of myopathy distal type 2 (MPD2) [MIM:606070]; also called vocal cord and pharyngeal dysfunction with distal myopathy (VCPDM). MPD2 is a muscular disorder characterized by distal weakness, with onset in hands and feet, associated with vocal cord and pharyngeal weakness causing a nasal voice and swallowing disorders.

Sequence similarities

Contains 1 matrin-type zinc finger.
Contains 2 RRM (RNA recognition motif) domains.

Cellular localization

Nucleus matrix.

Target information above from: UniProt accessionP43243 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • MATR3 antibody
  • MATR3_HUMAN antibody
  • Matrin-3 antibody
  • Matrin3 antibody

Database links

see all

Anti-Matrin 3 antibody images:

  Immunoprecipitation - Anti-Matrin 3 antibody (ab70336)

Immunoprecipitation - Anti-Matrin 3 antibody (ab70336)

Detection of Human Matrin 3 by Western Blot of Immunprecipitate. Lane 1: HeLa whole cell lysates immunoprecipitated using ab70336 at 3µg/mg lysate (1 mg/IP; 1/4 of IP loaded/lane). Lane 2: an irrelevant antibody was used for immunoprecipitation. All lanes: ab70336 at 3µg/ml. Detection: Chemiluminescence with an exposure time of 3 seconds.

References for Anti-Matrin 3 antibody (ab70336)

ab70336 has not yet been referenced specifically in any publications.

Publishing research using ab70336? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"