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Product Name
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Matriptase 2 peptide (Catalytic domain)
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Product type
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Proteins and Peptides
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Peptide
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Synthetic peptide Matriptase 2.
This peptide was used as an immunogen for ab42463 - Matriptase 2 antibody.
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Specificity
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We have a range of domain specific antibodies for this target. For a full list please see all Matriptase 2 antibodies
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Tested applications
(see key)
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ELISA, WB
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Application notes
(see key)
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Recommended dilutions
ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. This peptide can be used with studies using ab42463. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> TMPRSS
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> Matriptase
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> Other Enzymes
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Relevance
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Matriptase 2 is a type II serine proteinase. Matriptase 2 is an S1A family proteinase, in the PA clan of serine proteinases, which includes trypsin, chymotrypsin, acrosin, and many other key enzymes. A literature alias exists for MTSP2, the Mouse Serine Type Proteinase, granzyme A. Matriptase 2 is organized by an aminoterminal cytoplasmic domain, followed by a transmembrane domain, a stem region and then two CUB domains, three LDL receptor like motifs, and a carboxyterminal catalytic domain. Like matriptase 1, matriptase 2 is shed from the membrane by a cleavage in the stem region, and the catalytic domain can be cleaved from the regulatory domains to generate a free trypsin like enzyme. Matriptase 2 may be more limited in distribution than matriptase 1, and has been identified in the liver by message, but appears to be in kidney, liver and uterus, and in a number of cell lines.
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Purity
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>95% by SDS-PAGE
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Storage buffer
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Preservative: None
Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Matriptase 2 peptide (Catalytic domain) is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to Matriptase 2
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