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Overview

  • Product nameMeasles nucleoprotein protein
  • Protein descriptionRecombinant fragment, corresponding to amino acids 89-165 of Rubella Virus Nucleocapsid
  • Expression hostE. coli

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Purification notesab68493 is >95% pure as determined by 10% PAGE (coomassie staining) and RP-HPLC, purified by a proprietary chromatographic technique.
  • Biological activityThis protein is immunoreactive with sera of Measles Virus infected individuals.
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 50% Glycerol, 0.05% Sarkosyl, 60mM Sodium chloride, 50mM Tris HCl, 10mM Glutathione, pH 8
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab68493 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB WB: Use at an assay dependent dilution. Predicted molecular weight: 10 kDa.
    ELISA ELISA: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        Measles nucleocapsid proteinNNP
        NP proteinNucleocapsid proteinNucleoproteinProtein N
      see all
  • RelevanceInvolved in the encapsidating of the genome in a ratio of 1 N per 6 ribonucleotides, resulting in the protection from nucleases. The nucleocapsid (NC) has an helical structure with either 12.35 or 11.64 N per turn, approximately 20nm in diameter, with a hollow central cavity approximately 5nm in diameter. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases. N is released in the blood following lysis of measles infected cells, it interacts then with human FCGR2B on immune cells, inducing apoptosis and blocking inflammatory immune response. Ntail binds to a protein on human thymic epithelial cells, termed Nucleoprotein Receptor (NR), inducing growth arrest
  • Cellular localizationVirion. Host cytoplasm.

    • References for Measles nucleoprotein protein (ab68493)

    ab68493 has not yet been referenced specifically in any publications.

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