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Product Name
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Melatonin antibody
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See all Melatonin antibodies (2)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to Melatonin
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Immunogen
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c.BSA conjugate of 5-Methoxy-DL-tryptophan.
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Reacts with
(species key)
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N/A
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Specificity
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Reactivity :
Melatonin : 100%
5-Methoxy-DL-Tryptophan : 25%
N-acetyl-Tryptamine : =<0.1%
6-Hydroxy-Melatonin : <0.001%
N-acetyl-Tryptophan : =<0.1%
N-acetyl-Serotonin : =<0.01%
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Tested applications
(see key)
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ELISA
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA (hap-KLH, 50%B): 1/40.
ELISA (hap-KLH, EPT): 1/1250.
In competitive ELISA with 250 ng of KLH conjugate of 5-Methoxy-DL-tryptophan coated per well. 25 µl of standard, 25 µl of antibody at final dilution of 1/250.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Secreted
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Research areas
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Neuroscience >> Neurology process >> Circadian Rhythm >> Hormones
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Relevance
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Melatonin, the principal hormone of the pineal gland, is also produced by the retina, lens and GI tract. It is naturally synthesized from the amino acid tryptophan (via synthesis of serotonin) by the enzyme 5-hydroxyindole-O-methyltransferase.
Production of melatonin by the pineal gland is under the influence of the suprachiasmatic nucleus of the hypothalamus (SCN -the site of a circadian clock) which receives information from the retina about the daily pattern of light and darkness. Melatonin can alter the timing of mammalian circadian rhythms, as well as regulate the reproductive alterations that occur in response to changes in day length in seasonally breeding mammals.
Melatonin is also an extremely powerful antioxidant, with a particular role in the protection of nuclear and mitochondrial DNA.
Therapeutically there may be many potential uses for melatonin such as in the treatment of various forms of some forms of depression, cancer, HIV, plus other viral diseases. Currently, Melatonin is a popular therapy for jet-lag and disturbances of sleep.
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Melatonin antibody (ab35137) |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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IgG fraction
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Storage buffer
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Preservative: 0.1% Sodium Azide
Constituents: PBS, pH 7.2 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Purification notes
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Ammonium sulfate fractionation.
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Form
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Liquid
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Concentration
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5.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Melatonin antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to Melatonin
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Melatonin antibody - more information
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Customer reviews (feedback) regarding Melatonin antibody |
Customer FAQs regarding Melatonin antibody |
Protocols for Melatonin antibody |
Price and availability of products related to Melatonin antibody |
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Melatonin antibody - related products:
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Melatonin antibody - other tools:
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Contact Abcam with a Technical Enquiry about Melatonin antibody |
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