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Products:Neuroscience >> Neurology process >> Circadian Rhythm >> Hormones
Overview
Product name
Anti-Melatonin antibody
See all Melatonin products (2) ...
Description
Rabbit polyclonal to Melatonin
Specificity
Reactivity : Melatonin : 100% 5-Methoxy-DL-Tryptophan : 25% N-acetyl-Tryptamine : =<0.1% 6-Hydroxy-Melatonin : <0.001% N-acetyl-Tryptophan : =<0.1% N-acetyl-Serotonin : =<0.01%
Tested applications
ELISAmore details
Immunogen
c.BSA conjugate of 5-Methoxy-DL-tryptophan.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: PBS, pH 7.2
Concentration
Concentration information loading...
Purity
IgG fraction
Purification notes
Ammonium sulfate fractionation.
Clonality
Polyclonal
Isotype
IgG
Research areas
Neuroscience >> Neurology process >> Circadian Rhythm >> Hormones
Applications
Show applications key
Our Abpromise guarantee covers the use of ab35137 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: 1/40((hap-KLH, 50%B). ELISA (hap-KLH, EPT): 1/1250. In competitive ELISA with 250 ng of KLH conjugate of 5-Methoxy-DL-tryptophan coated per well. 25 µl of standard, 25 µl of antibody at final dilution of 1/250.)
Target
Relevance
Melatonin, the principal hormone of the pineal gland, is also produced by the retina, lens and GI tract. It is naturally synthesized from the amino acid tryptophan (via synthesis of serotonin) by the enzyme 5-hydroxyindole-O-methyltransferase. Production of melatonin by the pineal gland is under the influence of the suprachiasmatic nucleus of the hypothalamus (SCN -the site of a circadian clock) which receives information from the retina about the daily pattern of light and darkness. Melatonin can alter the timing of mammalian circadian rhythms, as well as regulate the reproductive alterations that occur in response to changes in day length in seasonally breeding mammals. Melatonin is also an extremely powerful antioxidant, with a particular role in the protection of nuclear and mitochondrial DNA. Therapeutically there may be many potential uses for melatonin such as in the treatment of various forms of some forms of depression, cancer, HIV, plus other viral diseases. Currently, Melatonin is a popular therapy for jet-lag and disturbances of sleep.
Cellular localization
Secreted
Alternative names
- 5-methoxy-N-acetyltryptamine antibody
- Melatonin antibody
- N acetyl 5 methoxytryptamine antibody
References for Anti-Melatonin antibody (ab35137)
This product has been referenced in:
- Han Yet al. Melatonin exerts by an autocrine loop antiproliferative effects in cholangiocarcinoma: its synthesis is reduced favoring cholangiocarcinoma growth. Am J Physiol Gastrointest Liver Physiol 301:G623-33 (2011). ELISA.Read more (PubMed: 21778461) »
See 1 publication for this product
Publishing research using ab35137? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"