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Product Name
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Melatonin peptide
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Product type
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Proteins and Peptides
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Peptide
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Melatonin (5-methoxytryptamine) conjugated with anhydride glutaric (AG) to bovine serum albumin (BSA).
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Tested applications
(see key)
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ICC, IHC-Fr
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Application notes
(see key)
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Recommended dilutions
ICC: Use at an assay dependent dilution.
IHC-Fr: Use at a concentration of 100 - 500 µg/ml.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Neuroscience >> Neurology process >> Circadian Rhythm >> Hormones
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Relevance
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Melatonin, the principal hormone of the pineal gland, is also produced by the retina, lens and GI tract. It is naturally synthesized from the amino acid tryptophan (via synthesis of serotonin) by the enzyme 5-hydroxyindole-O-methyltransferase.
Production of melatonin by the pineal gland is under the influence of the suprachiasmatic nucleus of the hypothalamus (SCN -the site of a circadian clock) which receives information from the retina about the daily pattern of light and darkness. Melatonin can alter the timing of mammalian circadian rhythms, as well as regulate the reproductive alterations that occur in response to changes in day length in seasonally breeding mammals.
Melatonin is also an extremely powerful antioxidant, with a particular role in the protection of nuclear and mitochondrial DNA.
Therapeutically there may be many potential uses for melatonin such as in the treatment of various forms of some forms of depression, cancer, HIV, plus other viral diseases. Currently, Melatonin is a popular therapy for jet-lag and disturbances of sleep.
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Storage buffer
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Reconstitute with deionized H2O + 0.1% merthiolate
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Purification notes
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Purification is done by dialysis.
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Form
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Lyophilised
Reconstitute with deionized H2O + 0.1% merthiolate
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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Notes
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This solution is stable at +4°C for 15 days.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Melatonin peptide is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to Melatonin
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Melatonin peptide - more information
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Customer reviews (feedback) regarding Melatonin peptide |
Customer FAQs regarding Melatonin peptide |
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Melatonin peptide - other tools:
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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