Overview

  • Product name
    Mepivacaine hydrochloride
  • Description
    Aminoamide local anesthetic. Voltage-gated Na+ channel blocker.
  • Biological description
    Aminoamide local anesthetic. Voltage-gated Na+ channel blocker (IC50 = 149 µM). Short onset time, intermediate duration and low toxicity. Similar to lidocaine. Prodrug that requires bioactivation by cytochrome P450. Active in vitro and in vivo.

Properties

  • Chemical name
    N-(2,6-Dimethylphenyl)-1-methylpiperidine-2-carboxamide hydrochloride
  • Molecular weight
    282.81
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C15H22N2O.HCl
  • CAS Number
    1722-62-9
  • PubChem identifier
    66070
  • Storage instructions
    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC1=C(C(=CC=C1)C)NC(=O)C2CCCCN2C.Cl
  • Source

    Synthetic

    References for Mepivacaine hydrochloride (ab143326)

    This product has been referenced in:
    • Tagariello V  et al. Mepivacaine: update on an evergreen local anaesthetic. Minerva Anestesiol 67:5-8 (2001). Read more (PubMed: 11778086) »
    • Harkins JD  et al. Mepivacaine: its pharmacological effects and their relationship to analytical findings in the horse. J Vet Pharmacol Ther 22:107-21 (1999). Read more (PubMed: 10372595) »
    • Park WK & Suh CK Mechanical and electrophysiological effects of mepivacaine on direct myocardial depression in vitro. Br J Anaesth 81:244-6 (1998). Read more (PubMed: 9813531) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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