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Overview

  • Product nameAnti-Mesothelin antibodySee all Mesothelin primary antibodies ...
  • Description
    Chicken polyclonal to Mesothelin
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide, corresponding to amino acids 361-580 of Human Mesothelin

Properties

Applications

Our Abpromise guarantee covers the use of ab53285 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/2000. Detects a band of approximately 75 kDa (predicted molecular weight: 69 kDa).

Target

  • FunctionMembrane-anchored forms may play a role in cellular adhesion.
    Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
  • Tissue specificityExpressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
  • Involvement in diseaseNote=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.
  • Sequence similaritiesBelongs to the mesothelin family.
  • Post-translational
    modifications    Both MPF and the cleaved form of mesothelin are N-glycosylated.
    Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
  • Cellular localizationSecreted and Cell membrane. Golgi apparatus.

    • Target information above from: UniProt accession Q13421 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        CAK 1 antibodyCAK1 antibodyCAK1 antigen antibody
        cleaved form antibodyMegakaryocyte potentiating factor antibodyMesothelin antibodyMesothelin isoform 1 precursor antibodyMPF antibodyMSLN antibodyMSLN_HUMAN antibodyPre pro megakaryocyte potentiating factor antibodyPre-pro-megakaryocyte-potentiating factor antibodySMR antibodySMRP antibodySoluble MPF mesothelin related protein antibody
      see all

    Anti-Mesothelin antibody images

    • Western blot - Mesothelin antibody (ab53285)
      Western blot - Mesothelin antibody (ab53285)
      Anti-Mesothelin antibody (ab53285) at 1/2000 dilution + E coli-derived fusion protein

      Secondary
      Goat anti-IgY-HRP at 1/1000 dilution

      Predicted band size : 69 kDa
      Observed band size : 75 kDa (why is the actual band size different from the predicted?)

    References for Anti-Mesothelin antibody (ab53285)

    ab53285 has not yet been referenced specifically in any publications.

    Publishing research using ab53285 ? Please let us know so that we can cite the reference in this datasheet

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